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ARAP1 Antibody

  • 货号：
    CSB-PA565827
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA565827(ARAP1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q96P48
  • 基因名：
  • 别名：
    2410002L19Rik antibody; ANK repeat and PH domain-containing protein 1 antibody; ARAP 1 antibody; Arap1 antibody; ARAP1_HUMAN antibody; Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domains containing protein 1 antibody; Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domain containing protein 1 antibody; Arf-GAP with Rho-GAP domain antibody; CENT D2 antibody; Centaurin delta 2 antibody; Centaurin delta2 antibody; Centaurin-delta-2 antibody; CENTD 2 antibody; CENTD2 antibody; Cnt d2 antibody; Cnt-d2 antibody; Cntd2 antibody; KIAA0782 antibody; MGC176140 antibody; mKIAA0782 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human ARAP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5.
  • 基因功能参考文献：
    1. Quantitative trait loci genes analysis reveals association between T2D risk variants at the ARAP1/STARD10 locus and STARD10 but not ARAP1 expression. PMID: 28132686
    2. Genetic variant rs1552224 of CENTD2 on chromosome 11 contributes to an independent effect as well as joint cumulative effect with rs2237897 of KCNQ1 on the risk of type 2 diabetes mellitus in Chinese Han population. PMID: 25749274
    3. The proinsulin-decreasing and T2D-risk Alleles are associated with increased ARAP1 mRNA levels in primary human pancreatic islets. PMID: 24439111
    4. a novel molecular mechanism of circular dorsal ruffles ring size control through the ARAP1-Arf1/5 pathway. PMID: 22573888
    5. Arap1 is highly expressed in the renal vasculature, and its expression is suppressed by angiotensin II. PMID: 22357923
    6. Of the lead variants from 12 novel type 2 diabetes associated loci, CENTD2 significantly associated with increased plasma glucose values and decreased glucose-stimulated insulin release. PMID: 21267535
    7. ARAP1 associated with CIN85 affects epidermal growth factor receptor endocytic trafficking PMID: 21275903
    8. PTK6 enhances EGFR signaling by inhibition of EGFR down-regulation through phosphorylation of ARAP1 in breast cancer cells. PMID: 20554524
    9. ARAP1 acts primarily on Arf6 in vivo. PMID: 18003747
    10. ARAP1 knockdown significantly compromises the localization of death receptor 4 at the cell surface of several tumor cell lines and slows down their TRAIL-induced death. PMID: 18165900
    11. ARAP1 controls the late steps of the endocytic trafficking of the EGF-R PMID: 18764928
    12. ARAP1 regulates the endocytic traffic of EGFR and, consequently, the rate of EGFR signal attenuation PMID: 18939958
    13. Data suggest that ARAP1 is recruited to membranes independently of PtdIns(3,4,5)P(3), the subsequent production of which triggers enzymatic activity. PMID: 19666464

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  • 亚细胞定位：
    Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane. Note=Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading.
  • 组织特异性：
    Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea.
  • 数据库链接：

    HGNC: 16925

    OMIM: 606646

    KEGG: hsa:116985

    STRING: 9606.ENSP00000377233

    UniGene: Hs.503165