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ARFIP2 Antibody

  • 货号：
    CSB-PA002003LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: ARFIP2 antibody at 2µg/ml + Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 38, 30, 34 kDa
      Observed band size: 38 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA002003LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA002003LA01HU at dilution of 1:100
    • Immunofluorescence staining of Hela cells with CSB-PA002003LA01HU at 1:120,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ARFIP2 Polyclonal antibody
  • Uniprot No.：
    P53365
  • 基因名：
    ARFIP2
  • 别名：
    ADP ribosylation factor interacting protein 2 antibody; ADP-ribosylation factor-interacting protein 2 antibody; Arfaptin 2 antibody; Arfaptin-2 antibody; ARFIP2 antibody; ARFP2_HUMAN antibody; FLJ18046 antibody; FLJ18697 antibody; FLJ99239 antibody; Partner of RAC1 antibody; POR1 antibody; Protein POR1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Arfaptin-2 protein (20-295AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ARFIP2 Antibody (CSB-PA002003LA01HU)，的标记方式是Non-conjugated。对于ARFIP2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA002003LB01HU ARFIP2 Antibody, HRP conjugated ELISA
    FITC CSB-PA002003LC01HU ARFIP2 Antibody, FITC conjugated
    Biotin CSB-PA002003LD01HU ARFIP2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site. In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG.
  • 基因功能参考文献：
    1. The data indicate that arfaptin 2 is the first molecule to regulate NF-kappaB signaling by interacting with the functional IkappaB kinase complex but not by direct inhibiting IKKbeta phosphorylation. PMID: 26296658
    2. both Arf1 activation and high membrane curvature are required for efficient recruitment of Arfaptin2 to membranes PMID: 23638170
    3. The binding of arfaptin1, but not arfaptin2, to PI(4)P is regulated by protein kinase D (PKD) mediated phosphorylation at Ser100 within the AH. PMID: 23695357
    4. The Arl1.Arfaptin-2 BAR structure suggests that one of the two Arl1 molecules competes with Rac1, which binds to the concave face of the Arfaptin-2 BAR homodimer and may hinder its membrane association. PMID: 22679020
    5. arfaptin 2 is involved in regulating huntingtin protein aggregation PMID: 11854752
    6. arfaptin 2 phosphorylation at Ser260 by Akt inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment PMID: 15809304

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  • 亚细胞定位：
    Golgi apparatus. Golgi apparatus, trans-Golgi network membrane.
  • 数据库链接：

    HGNC: 17160

    OMIM: 601638

    KEGG: hsa:23647

    STRING: 9606.ENSP00000254584

    UniGene: Hs.732203