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ARHGAP26 Antibody

  • 货号：
    CSB-PA892479ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA892479ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA892479ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ARHGAP26 Polyclonal antibody
  • Uniprot No.：
    Q9UNA1
  • 基因名：
    ARHGAP26
  • 别名：
    arhgap26 antibody; FLJ42530 antibody; GRAF antibody; GRAF1 antibody; GTPase regulator associated with focal adhesion kinase antibody; GTPase regulator associated with focal adhesion kinase pp125(FAK) antibody; KIAA0621 antibody; oligophrenin 1 like protein antibody; Oligophrenin-1-like protein antibody; oligophrenin1like protein antibody; OPHN1L antibody; OPHN1L1 antibody; RHG26_HUMAN antibody; Rho GTPase activating protein 26 antibody; Rho GTPase activating protein26 antibody; Rho GTPase-activating protein 26 antibody; Rho-type GTPase-activating protein 26 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Rho GTPase-activating protein 26 protein (625-814AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    GTPase-activating protein for RHOA and CDC42.
  • 基因功能参考文献：
    1. GRAF1 plays a role in the maintenance of normal epithelial phenotype and its depletion leads to an epithelial-mesenchymal transition-like process that might be involved in neoplastic transformation. PMID: 27588930
    2. We conclude that a transient interaction between Cdc42 and GRAF1 drives endocytic turnover and controls the transition essential for endosomal maturation of plasma membrane internalised by this mechanism. PMID: 26446261
    3. GRAF expression is a favorable prognostic marker in patients with acute myeloid leukemia. PMID: 25088035
    4. ADAR1 regulates the expression of ARHGAP26 through A-to-I RNA editing by disrupting the binding of miR-30b-3p and miR-573 within the 3' UTR of ARHGAP26. PMID: 24067935
    5. proposed that GRAF1 remodels membrane microdomains at adhesion sites into endocytic carriers, facilitating membrane turnover during cell morphological changes PMID: 21965292
    6. Findings suggest that the hypermethylation of GRAF promoter might be one of early events in the development of AML. PMID: 21074269
    7. a GTPase-activating protein that regulates muscle maturation and to highlight the functional importance of BAR domains in myotube formation PMID: 21622574
    8. Decreased level of GRAF transcript is associated with acute myeloid leukemia, myelodysplastic syndrome and chronic myeloid leukemia. PMID: 20704716
    9. The GRAF gene was down-regulated in AML, which might play a role in the leukemogenesis. PMID: 20533268
    10. The analysis of the expression pattern of the GRAF1/OPHN-1-L gene in human tissues and organs revealed the predominant brain expression of a novel splicing isoform. PMID: 20602808
    11. abnormal GRAF methylation might be an adverse prognostic event in MDS PMID: 20374274
    12. Graf residues important for the structural integrity are critical for binding RhoA and for the catalytic activity of GAP, but GTPase selectivity appears to be modulated by a more subtle interplay involving residues on the periphery of the main interface. PMID: 18929667
    13. GRAF is a negative regulator of RhoA in vivo, it acts as a GTP-ase activating protein (GAP) for RhoA and may be a downstream effector of RhoA in certain cell types. PMID: 9858476

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  • 相关疾病：
    Leukemia, juvenile myelomonocytic (JMML)
  • 亚细胞定位：
    Cell junction, focal adhesion. Cytoplasm, cytoskeleton.
  • 数据库链接：

    HGNC: 17073

    OMIM: 605370

    KEGG: hsa:23092

    STRING: 9606.ENSP00000274498

    UniGene: Hs.654668