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ARHGAP32 Antibody

  • 货号：
    CSB-PA415667LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of SH-SY5Y cells with CSB-PA415667LA01HU at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ARHGAP32 Polyclonal antibody
  • Uniprot No.：
    A7KAX9
  • 基因名：
    ARHGAP32
  • 别名：
    ARHGAP32 antibody; GRIT antibody; KIAA0712 antibody; RICS antibody; Rho GTPase-activating protein 32 antibody; Brain-specific Rho GTPase-activating protein antibody; GAB-associated Cdc42/Rac GTPase-activating protein antibody; GC-GAP antibody; GTPase regulator interacting with TrkA antibody; Rho-type GTPase-activating protein 32 antibody; Rho/Cdc42/Rac GTPase-activating protein RICS antibody; RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling antibody; p200RhoGAP antibody; p250GAP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Rho GTPase-activating protein 32 protein (130-205AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ARHGAP32 Antibody (CSB-PA415667LA01HU)，的标记方式是Non-conjugated。对于ARHGAP32 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA415667LB01HU ARHGAP32 Antibody, HRP conjugated ELISA
    FITC CSB-PA415667LC01HU ARHGAP32 Antibody, FITC conjugated
    Biotin CSB-PA415667LD01HU ARHGAP32 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity.
  • 基因功能参考文献：
    1. Cdh1-APC together with the RhoA regulators p250GAP and Smurf1 controls axon growth in the mammalian brain PMID: 23226367
    2. the p250GAP gene might be a new candidate gene for susceptibility to schizophrenia. PMID: 22530067
    3. These results suggest that Grit, a novel TrkA-interacting protein, regulates neurite outgrowth by modulating the Rho family of small GTPases. PMID: 12446789
    4. involvement in the regulation of neurite outgrowth by exerting its RhoGAP activity and that its cellular activity may be regulated through interaction with Src-like tyrosine kinases PMID: 12454018
    5. This article analyzes Rac activation during live neutrophil chemotaxis. PMID: 12477392
    6. RICS may regulate dendritic spine morphology and strength by modulating Rho GTPases PMID: 12531901
    7. is phosphorylated by Fyn in oligodendrocytes PMID: 12788081
    8. GC-GAP may play a role in dendritic morphogenesis and also possibly in neural/glial cell proliferation PMID: 12819203
    9. p250GAP is likely to be involved in actin reorganization in dendritic spines PMID: 12857875
    10. Results suggest that a splice variant of RICS, PX-RICS, is involved in early brain development including extension of axons and dendrites, and postnatal remodeling and fine-tuning of neural circuits. PMID: 17663722
    11. Results suggest that PX-RICS ensures the efficient entry of the N-cadherin/beta-catenin complex into the secretory pathway, and thereby regulates the amount of N-cadherin available for cell adhesion and FGFR4-mediated signaling. PMID: 18451111
    12. miR132-p250GAP pathway plays a key role in activity-dependent structural and functional plasticity. PMID: 18577589
    13. p250GAP may be involved in NMDA receptor activity-dependent actin reorganization in dendritic spines PMID: 12857875

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic density. Cell projection, dendritic spine. Cytoplasm, cell cortex. Endosome membrane. Golgi apparatus membrane. Endoplasmic reticulum membrane. Membrane.
  • 蛋白家族：
    PX domain-containing GAP family
  • 组织特异性：
    Isoform 1 and isoform 2 are highly expressed in brain and testis. Isoform 1 is also expressed in other tissues such as lung, liver and spleen.
  • 数据库链接：

    HGNC: 17399

    OMIM: 608541

    KEGG: hsa:9743

    STRING: 9606.ENSP00000310561

    UniGene: Hs.440379