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ARHGEF5 Antibody

  • 货号：
    CSB-PA002053GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q12774
  • 基因名：
    ARHGEF5
  • 别名：
    ARHG5_HUMAN antibody; ARHGEF 5 antibody; ARHGEF5 antibody; DKFZp686N1969 antibody; ephexin 3 antibody; Ephexin-3 antibody; GEF 5 antibody; GEF5 antibody; Guanine nucleotide regulatory protein TIM antibody; Oncogene TIM antibody; P60 antibody; p60 TIM antibody; Rho guanine nucleotide exchange factor (GEF) 5 antibody; Rho guanine nucleotide exchange factor 5 antibody; TIM 1 antibody; TIM antibody; TIM1 antibody; Transforming immortalized mammary oncogene antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ARHGEF5
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1. Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation. Involved in positive regulation of immature dendritic cell migration.
  • 基因功能参考文献：
    1. Tim protein and DDX11 physically and functionally interact and act in concert to preserve replication fork progression in perturbed conditions. PMID: 26503245
    2. Data indicate that Rho guanine nucleotide exchange factor 5 (ARHGEF5) is expressed in most human lung adenocarcinoma tissues and cell lines. PMID: 25777963
    3. Targeting rho guanine nucleotide exchange factor ARHGEF5/TIM with auto-inhibitory peptides in human breast cancer. PMID: 25743165
    4. The auto-inhibitory state of Rho guanine nucleotide exchange factor ARHGEF5/TIM can be relieved by targeting its SH3 domain with rationally designed peptide aptamers. PMID: 25645980
    5. In conclusion, ARHGEF5/Src can be considered as a prognostic biomarker and a therapeutic target for patients with resected NSCLC. PMID: 24126923
    6. A receiver operating characteristic curve constructed with HSP105 and TIM gave a sensitivity of 54.3% and 95% (38/40) specificity in discriminating esophageal squamous cell carcinoma from matched controls. PMID: 24157810
    7. This study performed whole exome sequencing demonistrated that the true de novo variants represent mutations in genes (KCNH5, CLCN4, and ARHGEF15) not previously associated with epilepsies in humans. PMID: 23647072
    8. Tim-Tipin complex might play a role in coupling DNA unwinding and DNA synthesis by directly affecting the catalytic activities of replication fork proteins. PMID: 23359676
    9. Overexpression of Arhgef5 promoted actin stress fiber remodeling through activating RhoA, and the activation of RhoA or Cdc42 was required for Src-induced podosome formation. PMID: 21525037
    10. association in humans of TIM-1 and hypersensitivity and the relationship between TIM1, hygiene, and the environment. PMID: 15681748
    11. The expression level of TIM was decreased in hepatocellular carcinoma. PMID: 18444243
    12. RhoA guanine nucleotide exchange factor Arhgef5 regulates immature dendritic cell migration PMID: 19713215

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cell projection, podosome.
  • 组织特异性：
    Ubiquitously expressed with highest levels in placenta. High levels are also found in colon, kidney, trachea, prostate, liver, pancreas, pituitary gland, thyroid gland and mammary gland. In fetal tissues, expressed at high levels in kidney, lung and liver
  • 数据库链接：

    HGNC: 13209

    OMIM: 600888

    KEGG: hsa:7984

    STRING: 9606.ENSP00000056217

    UniGene: Hs.334