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ARHGEF6 Antibody

  • 货号：
    CSB-PA618974LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA618974LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ARHGEF6 Polyclonal antibody
  • Uniprot No.：
    Q15052
  • 基因名：
  • 别名：
    Alpha Pix antibody; Alpha-Pix antibody; ARHG6_HUMAN antibody; ARHGEF6 antibody; COOL 2 antibody; COOL-2 antibody; COOL2 antibody; Mental retardation; X linked 46 antibody; MRX46 antibody; PAK interacting exchange factor alpha antibody; PAK-interacting exchange factor alpha antibody; PIXA antibody; Rac/Cdc42 guanine exchange factor (GEF) 6 antibody; Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 antibody; Rac/Cdc42 guanine nucleotide exchange factor 6 antibody; Rho guanine nucleotide exchange factor 6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Rho guanine nucleotide exchange factor 6 protein (108-239AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ARHGEF6 Antibody (CSB-PA618974LA01HU)，的标记方式是Non-conjugated。对于ARHGEF6 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA618974LB01HU ARHGEF6 Antibody, HRP conjugated ELISA
    FITC CSB-PA618974LC01HU ARHGEF6 Antibody, FITC conjugated
    Biotin CSB-PA618974LD01HU ARHGEF6 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a RAC1 guanine nucleotide exchange factor (GEF).
  • 基因功能参考文献：
    1. In this first X chromosome-wide association study of adult patients with IBD, we identified an IBD susceptibility locus with genome-wide significance at rs2427870 on chrXq26.3, located 66 kbp upstream of CD40LG and 83.4 kbp upstream of ARHGEF6 [OR, 1.22; combined p = 3.79 x 10-15]. PMID: 28333213
    2. show that ARHGEF6 is constitutively linked to GIT1, a GAP of Arf family small G proteins, and that ARHGEF6 phosphorylation enables binding of the 14-3-3 adaptor protein to the ARHGEF6/GIT1 complex PMID: 26507661
    3. The novel recycling regulator alpha-PIX and the degradation factor c-Cbl closely cooperate in the regulation of EGFR trafficking. PMID: 26177020
    4. c-Cbl negatively regulates alphaPix-mediated cell migration and invasion; the lack of c-Cbl in C6 and A172 glioma cells is responsible for their malignant behavior PMID: 25450678
    5. results suggest that low doses of chlorambucil and very low doses of chronic oxidative stress together kill Cbl-resistant ovarian carcinoma cells and ARHGEF6 signaling may have an instrumental role in induction of apoptosis in Cbl(cos) cells. PMID: 19918261
    6. These findings suggest that alpha Pix plays an important role in mutant huntingtin aggregation. PMID: 19969308
    7. The interaction of alphaPix with CagA activates PAK1, ERK and NF-kappaB, which induces IL-8 expression in H. pylori-infected gastric epithelial cells. PMID: 19672789
    8. The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding PMID: 11937491
    9. Expression of Cbl-b effectively blocks the ability of Cool-2 to stimulate PAK, providing an additional mechanism, aside from catalyzing receptor ubiquitination, by which Cbl-b acts as a negative regulator for signaling activities requiring PAK activation. PMID: 12935897
    10. Data suggest that Rac-dependent activation of the NFkappaB pathway may be a critical element promoting thrombin-induced tissue factor expression and activity, and thus a prothrombotic state in pulmonary hypertension. PMID: 15242552
    11. Whereas alphaPIX guanine nucleotide exchange factor activity contributes to enhanced formation of cellular protrusions, the GEF-independent association with calpain 4 leads to induction of a yet unknown signaling cascade resulting in cell spreading. PMID: 15611136
    12. Semi-quantitative RT-PCR experiments with 6 of those genes confirmed higher expression of DNCH2, ARHGEF6, NPM1 and SRI and lower expression of NRGN and TM4SF2 in GBM tumors. PMID: 16320026
    13. PAK4 and alphaPIX can induce highly localized changes in actin dynamics and thereby regulate size and number of podosomes in primary human macrophages. PMID: 16897755
    14. phosphorylation of CagA induces the dephosphorylation of alpha-Pix, which may modulate cytoskeletal changes of gastric epithelial cells through PAK PMID: 17405911

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  • 相关疾病：
    Mental retardation, X-linked 46 (MRX46)
  • 亚细胞定位：
    Cell projection, lamellipodium.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 685

    OMIM: 300267

    KEGG: hsa:9459

    STRING: 9606.ENSP00000250617

    UniGene: Hs.522795