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  4. ARMC8 Antibody

ARMC8 Antibody

  • 货号：
    CSB-PA002110GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8IUR7
  • 基因名：
    ARMC8
  • 别名：
    Armadillo repeat containing protein 8 antibody; Armadillo repeat-containing protein 8 antibody; ARMC8 antibody; ARMC8_HUMAN antibody; HSPC056 antibody; MGC10058 antibody; MGC4880 antibody; S863 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ARMC8
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.
  • 基因功能参考文献：
    1. Knockdown of ARMC8 significantly inhibited osteosarcoma cell proliferation in vitro and markedly inhibited xenograft tumor growth in vivo. ARMC8 silencing also suppressed the epithelial-mesenchymal transition (EMT) phenotype, as well as inhibited the migration and invasion of osteosarcoma cells. PMID: 27712595
    2. results indicate that Armc8 may be a potential cancer marker in hepatocellular carcinoma PMID: 26944057
    3. invasiveness and migration capacity of HT29 cells transfected with ARMc8 were significantly greater than those of control cells (p < 0.001), while ARMc8 siRNA treatment significantly reduced cell invasion and migration in LoVo cells PMID: 26081621
    4. ARMc8 may enhance the invasion and metastasis of ovarian cancer cells PMID: 26232863
    5. Armc8 expression was elevated during atypia-to-carcinoma progression and associated with cancer development of breast carcinoma. PMID: 25119601
    6. Data suggest that armadillo repeat containing protein 8 (ARMC8) might serve as a therapeutic target in non-small cell lung cancer (NSCLC). PMID: 24894675

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 数据库链接：

    HGNC: 24999

    KEGG: hsa:25852

    STRING: 9606.ENSP00000420333

    UniGene: Hs.744868