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  4. ARR3 Antibody

ARR3 Antibody

  • 货号：
    CSB-PA009894
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P36575
  • 基因名：
    ARR3
  • 别名：
    ARR3 antibody; ARR4 antibody; ARRC_HUMAN antibody; Arrestin 3 retinal antibody; Arrestin 3 retinal (X-arrestin) antibody; Arrestin 4 antibody; Arrestin-C antibody; ARRX antibody; C arrestin antibody; C-arrestin antibody; CAR antibody; cArr antibody; Cone arrestin antibody; Retinal cone arrestin 3 antibody; Retinal cone arrestin-3 antibody; X arrestin antibody; X-arrestin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human Arrestin-C.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins.
  • 基因功能参考文献：
    1. These data suggest that heterozygous mutations in ARR3 might be responsible for X-linked female-limited early onset high myopia in the three families, a pattern contrary to the standard X-linked recessive trait. PMID: 27829781
    2. In the cell membrane, arrestin-3 dissociates quickly and almost completely from the Beta2-adrenoceptor. PMID: 25425623
    3. Identification of receptor binding-induced conformational changes in non-visual arrestins. PMID: 24867953
    4. The 25-amino acid N-domain element of arrestin 3 has the highest affinity for JNK3alpha2, suggesting that it is the key site for JNK3alpha2 docking. PMID: 24412749
    5. arrestin-3 regulates the activity of multiple JNK isoforms, suggesting that it might play a role in survival and apoptosis of all cell types. PMID: 24292834
    6. Silent scaffolds: inhibition OF c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant. PMID: 22523077
    7. PP2A inhibits association between the Na+,K+-ATPase and arrestin, and diminishes the effect of arrestin on Na+,K+-ATPase trafficking. PMID: 22242112
    8. upon ligand activation, CysLT(1)R is tyrosine-phosphorylated and released from heterodimers with CysLT(2)R and, subsequently, internalizes from the plasma membrane to the nuclear membrane in a clathrin-, arrestin-3-, and Rab-5-dependent manner PMID: 21203429
    9. two non-visual arrestins, arrestin2 and arrestin3, localize to the centrosome, a key organelle involved in microtubule nucleation and bipolar mitotic spindle assembly PMID: 20056609
    10. Regulation of arrestin-3 phosphorylation by casein kinase II. PMID: 11877451
    11. The light-dependent translocation of cone arrestin suggests a role in light-dark adaptation of cones. PMID: 12824223
    12. association of arrestin-3 with the FSHR is dependent on receptor phosphorylation, however phosphorylation of the third intracellular loop residues is not needed for arrestin-3 association. PMID: 12850288
    13. Autoimmunity to this antigen and retinal vasculitis is not altered in patients with Behcet's disease PMID: 12918707
    14. Arrestin in all conformations binds JNK3 comparably, whereas Mdm2 preferentially binds cone arrestin 'frozen' in the basal state. PMID: 17680991
    15. Arrestin 3 but not arrestin 2 is required for internalization of C-C chemokine receptor CCR7 when bound to C-C chemokine ligand CCL19. In contrast, arrestins are not required for internalization of CCR7/CCL21. PMID: 18802075
    16. the molecular interactions of arrestin2 and arrestin3 and their individual domains with the components of the two MAPK cascades, ASK1-MKK4-JNK3 and c-Raf-1-MEK1-ERK2 PMID: 19001375

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  • 亚细胞定位：
    Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment.
  • 蛋白家族：
    Arrestin family
  • 组织特异性：
    Inner and outer segments, and the inner plexiform regions of the retina.
  • 数据库链接：

    HGNC: 710

    OMIM: 301770

    KEGG: hsa:407

    STRING: 9606.ENSP00000311538

    UniGene: Hs.308