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ASCL2 Antibody

  • 货号：
    CSB-PA010204
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q99929
  • 基因名：
    ASCL2
  • 别名：
    ASCL2 antibody; BHLHA45 antibody; HASH2Achaete-scute homolog 2 antibody; ASH-2 antibody; hASH2 antibody; Class A basic helix-loop-helix protein 45 antibody; bHLHa45 antibody; Mash2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Mash2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
  • 基因功能参考文献：
    1. this study shows that Ascl2 level was higher in peripheral blood mononuclear cells from Sjogren's syndrome patients compared with those from healthy controls PMID: 28728856
    2. A novel HIF-1alpha/Ascl2/miR-200b regulatory feedback circuit in modulating EMT-MET plasticity of CRC cells, which could serve as a possible therapeutic target. PMID: 28899657
    3. WiNTRLINC1 interacts with TCF4/beta-catenin to mediate the juxtaposition of its promoter with the regulatory regions of ASCL2. PMID: 27292638
    4. Ascl2 over-expression is associated with colorectal neoplasms. PMID: 26307678
    5. expression of ASCL2 may identify an aggressive subgroup in lung squamous cell carcinoma PMID: 26483561
    6. SEMA3F functions as a suppressor of colorectal cancer metastasis by down-regulating the ASCL2-CXCR4 signaling axis. PMID: 25866254
    7. SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. PMID: 25277775
    8. ASCL2 gene expression is regulated by miR-200a/b/c, miR-141 and miR429 levels in colon cancer. PMID: 25371200
    9. Ascl2 directly initiates follicular T-helper cell development PMID: 24463518
    10. These results suggest that ASCL2 might play an important role in gastric tumor growth and chemoresistance. PMID: 23181270
    11. Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells PMID: 22384170
    12. a stem cell specific transcription signature promoted by ASCL2 has been identified to be upregulated in a subset of liver metastases, those characterised by an 11p15.5 gain PMID: 20479215
    13. These findings suggest that increased protein levels and DNA binding of USF1 and USF2 mediate the inhibitory effects of hypoxia and of Mash-2 on CYP19 gene expression in human placenta PMID: 12917334
    14. These results suggest that PACE4 expression is down-regulated by Hash-2/Mash-2 in both human and rat placenta and that many bioactive proteins might be regulated by PACE4 activity. PMID: 14561729
    15. ascl2 is a putative regulator of proliferation that is overexpressed in intestinal neoplasia PMID: 16568095
    16. Negative expression of HASH2 in complete hydatidiform moles (CM) but positive expression in malignant tumors suggests the presence of a specific mechanism for inactivation of the HASH2 gene in CM and reactivation in invasive moles or choriocarcinoma PMID: 17165436

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed specifically in the extravillous trophoblasts of the developing placenta.
  • 数据库链接：

    HGNC: 739

    OMIM: 601886

    KEGG: hsa:430

    STRING: 9606.ENSP00000332293

    UniGene: Hs.152475