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ASH1L Antibody

  • 货号：
    CSB-PA865114LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA865114LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA865114LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA865114LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ASH1L Polyclonal antibody
  • Uniprot No.：
    Q9NR48
  • 基因名：
    ASH1L
  • 别名：
    Absent small and homeotic disks protein 1 homolog antibody; Absent Small or Homeotic Like antibody; Absent Small or Homeotic Like antibody; ASH 1 antibody; ASH 1L antibody; ash1 (absent small or homeotic 1) antibody; Ash1 (absent small or homeotic) like antibody; ASH1-like protein antibody; ASH1L antibody; ASH1L_HUMAN antibody; ASH1L1 antibody; FLJ10504 antibody; huASH1 antibody; KIAA1420 antibody; KMT2H / ASH1 antibody; Lysine N-methyltransferase 2H antibody; Probable histone-lysine N-methyltransferase ASH1L antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Histone-lysine N-methyltransferase ASH1L protein (1906-2160AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ASH1L Antibody (CSB-PA865114LA01HU)，的标记方式是Non-conjugated。对于ASH1L Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA865114LB01HU ASH1L Antibody, HRP conjugated ELISA
    FITC CSB-PA865114LC01HU ASH1L Antibody, FITC conjugated
    Biotin CSB-PA865114LD01HU ASH1L Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The physiological significance of the H3K9me1 activity is unclear.
  • 基因功能参考文献：
    1. DDB2 promotes cyclobutane pyrimidine dimer excision by recruiting the histone methyltransferase ASH1L, which methylates lysine 4 of histone H3. In turn, methylated H3 facilitates the docking of the XPC complex to nucleosomal histone octamers. PMID: 29109511
    2. suppresses matrix metalloproteinase through mitogen-activated protein kinase signaling pathway in pulpitis PMID: 28041684
    3. There has been increasing evidence that heterozygous mutation of ASH1L is associated with ID and autism spectrum disorders. We suggest that ASH1L abnormalities may cause a novel MCA/ID syndrome. PMID: 28394464
    4. Epigenetic regulators play vital roles in cancer pathogenesis and represent a new frontier in therapeutic targeting. Our studies provide basic mechanistic insight into the role of H3K36me2 in transcription activation and MLL leukemia pathogenesis and implicate ASH1L histone methyltransferase as a promising target for novel molecular therapy. PMID: 27154821
    5. Our data suggest a role for ASH1L, a methyl transferase protein and member of the trithorax (Trx) family, in regulation of the HBB gene and as a potential modifier of beta-thalassaemia severity. PMID: 27434206
    6. Structural features were identified in ASH1L related to its' function and enzymatic activity. PMID: 26292256
    7. Both ASH1L and SETD2 are H3K36 specific methyltransferases but only SETD2 can trimethylate this mark. PMID: 26002201
    8. These data demonstrate that miR-142-3p downregulation has a role in thyroid tumorigenesis, by regulating ASH1L and MLL1. PMID: 25238203
    9. Our results uncover a novel regulatory cascade orchestrated by Ash1l with RAR and provide insights into mechanisms underlying the establishment of the transcriptional activation that counteracts Polycomb silencing PMID: 24244179
    10. all of the H3K36-specific methyltransferases, including ASH1L, HYPB, NSD1, and NSD2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a, and Pr-Set7 were not affected by ubH2A. PMID: 24019522
    11. induction of Cdk5 activity is a novel mechanism through which hASH1 may regulate migration in lung carcinogenesis PMID: 22696682
    12. Long Non-coding RNA, DBE-T recruits the Trithorax group protein Ash1L to the FSHD locus, driving histone H3 lysine 36 dimethylation, chromatin remodeling, and 4q35 gene transcription. PMID: 22541069
    13. ASH1 and MLL1 synergize in activation of Hox genes. PMID: 22140534
    14. human ASH1L specifically methylates histone H3 Lys-36. PMID: 21239497
    15. These data suggest that ASH1L occupies most, if not all, active genes and methylates histone H3 in a nonredundant fashion at a subset of genes. PMID: 17923682

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  • 亚细胞定位：
    Nucleus. Cell junction, tight junction. Chromosome.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SET2 subfamily
  • 组织特异性：
    Widely expressed, with highest level in brain, heart and kidney.
  • 数据库链接：

    HGNC: 19088

    OMIM: 607999

    KEGG: hsa:55870

    STRING: 9606.ENSP00000376204

    UniGene: Hs.491060