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ATG16L2 Antibody

  • 货号：
    CSB-PA843310HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA843310HA01HU diluted at 1:700 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA843310HA01HU diluted at 1:700 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescent analysis of HepG2 cells using CSB-PA843310HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ATG16L2 Polyclonal antibody
  • Uniprot No.：
    Q8NAA4
  • 基因名：
  • 别名：
    A16L2_HUMAN antibody; APG16-like 2 antibody; ATG16 autophagy related 16-like 2 antibody; ATG16B antibody; Atg16l2 antibody; autophagy related 16-like 2 (S. cerevisiae) antibody; Autophagy-related protein 16-2 antibody; WD repeat-containing protein 80 antibody; WDR80 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Autophagy-related protein 16-2 protein (262-348AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ATG16L2 Antibody (CSB-PA843310HA01HU)，的标记方式是Non-conjugated。对于ATG16L2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA843310HB01HU ATG16L2 Antibody, HRP conjugated ELISA
    FITC CSB-PA843310HC01HU ATG16L2 Antibody, FITC conjugated
    Biotin CSB-PA843310HD01HU ATG16L2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner.
  • 基因功能参考文献：
    1. ATG16L2 is a susceptibility gene for Crohn's disease in the Chinese population. The rs11235604 single nucleotide polymorphism is remarkably associated with downregulation of the expression of ATG16L2. PMID: 27611316
    2. A novel SNP-systemic lupus erythematosus association was identified between FCHSD2 and P2RY2, peaking at rs11235667 on a 33-kb haplotype upstream of ATG16L2. PMID: 26663301
    3. Atg16L2 may play an important role in autophagy of T cells and serve as a potential biomarker to predict clinical relapse of Multiple sclerosis PMID: 24406150
    4. Three novel risk loci including ATG16L2 were discovered by genome-wide association study in the Korean Crohn's disease population, of which two showed patterns of association in the International Inflammatory Bowel Disease Genetics Consortium dataset. PMID: 23850713
  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    WD repeat ATG16 family
  • 数据库链接：

    HGNC: 25464

    KEGG: hsa:89849

    STRING: 9606.ENSP00000326340

    UniGene: Hs.653186