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ATP2B2 Antibody

  • 货号：
    CSB-PA002336DSR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA002336DSR1HU at dilution of 1:100
    • Immunofluorescent analysis of 293 cells using CSB-PA002336DSR1HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ATP2B2 Polyclonal antibody
  • Uniprot No.：
    Q01814
  • 基因名：
  • 别名：
    AT2B2_HUMAN antibody; atp2b2 antibody; ATPase plasma membrane Ca2+ transporting 2 antibody; Plasma membrane calcium ATPase 2 antibody; Plasma membrane calcium ATPase antibody; Plasma membrane calcium ATPase isoform 2 antibody; Plasma membrane calcium pump isoform 2 antibody; Plasma membrane calcium transporting ATPase 2 antibody; Plasma membrane calcium-transporting ATPase 2 antibody; PMCA2 antibody; PMCA2a antibody; PMCA2i antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Plasma membrane calcium-transporting ATPase 2 protein (1-80AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning. Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia. In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels. In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk.
  • 基因功能参考文献：
    1. PMCA2 regulates breast cancer cell proliferation and sensitivity to doxorubicin in basal cell carcinoma. PMID: 27148852
    2. Cytoskeleton dynamics regulates plasma membrane PMCA2 activity. PMID: 28527708
    3. Data show that ATPase, calcium transporting, plasma membrane 2 protein (PMCA2) silencing augmented B-cell leukemia 2 family proteins (Bcl-2) inhibitor ABT-263-mediated MDA-MB-231 breast cancer cell death. PMID: 27613092
    4. NHERF1 acts with PMCA2 to regulate HER2 signaling and membrane retention in breast cancers PMID: 28235801
    5. PMCA2 interacts with HER2 in specific actin-rich membrane domains. PMID: 26729871
    6. PMCA2b resulted in rapid and highly PMCA abundance-sensitive clearance of store-operated Ca2+ entry-mediated Ca2+ transients. PMID: 25690014
    7. ATP2B2 might play a role in the etiology of autism in Chinese Han population. PMID: 23620727
    8. G293S and V586M mutations in the PMCA2 Calcium Transporting ATPase of the stereocilia are associated with deafness. (Review) PMID: 22349217
    9. The human mutant of PMCA2 exacerbated the deafness produced by a cadherin 23 mutation. The human mutant failed to impair the Ca(2+) ejection by the pump. PMID: 22047666
    10. These results provide converging evidence for an association between ATP2B2 gene variants and autism in male subjects PMID: 21757185
    11. these data suggest that full polarization is a prerequisite for proper positioning of the PMCA2w variants in the apical membrane domain of polarized cells. PMID: 21672522
    12. It appears that Ca extrusion via the sarcolemmal Ca ATPase occurs only at the t-tubules, and is not regulated by basal PKA activity. PMID: 20971118
    13. Report a novel interaction between endogenous plasma membrane calcium ATPase (PMCA) and eNOS in endothelial cells. PMCA may negatively modulate eNOS activity, and NO-dependent signal transduction pathways. PMID: 20211863
    14. Apical scaffolding protein NHERF2 modulates the localization of alternatively spliced plasma membrane Ca2+ pump 2B variants in polarized epithelial cells. PMID: 20663896
    15. Alternative splicing of the first intracellular loop of PMCA2 alters its membrane targeting PMID: 12624087
    16. Decrease in PMCA2 transcript and protein levels and correlation between expression and disease course in two different allergic encephalomyelitis models further highlight the importance of this calcium pump in neuronal dysfunction during inflammation. PMID: 15926914
    17. We conclude that PMCA2 mRNA can be highly overexpressed in some breast cancer cells. PMID: 16216224
    18. plasma-membrane calcium-pump isoform 2 mutants have roles in causing digenic deafness PMID: 17234811
    19. Our results indicate that a loss of PMCA such as occurs in aging brain likely leads to subtle disruptions in normal Ca(2+) signaling and enhanced susceptibility to stresses that can alter the regulation of Ca(2+) homeostasis. PMID: 17488275
    20. The deaf-waddler isoform of PMCA2, operating at 30% efficacy, showed a significantly decreased ability to rescue the Ca(2+) loading of cells expressing TRPML3(A419P). PMID: 19299509
    21. These data indicate that alternative splicing differentially affects the lipid interactions of PMCA2w/b and PMCA2z/b and that the apical localization of PMCA2w/b is lipid raft-dependent and sensitive to cholesterol depletion. PMID: 19379709
    22. Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 19850283

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse.; [Isoform WA]: Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.; [Isoform WB]: Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.; [Isoform XB]: Basolateral cell membrane; Multi-pass membrane protein.; [Isoform ZA]: Basolateral cell membrane; Multi-pass membrane protein.; [Isoform ZB]: Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIB subfamily
  • 组织特异性：
    Mainly expressed in brain cortex. Found in low levels in skeletal muscle, heart muscle, stomach, liver, kidney and lung. Isoforms containing segment B are found in brain cortex and at low levels in other tissues. Isoforms containing segments X and W are f
  • 数据库链接：

    HGNC: 815

    OMIM: 108733

    KEGG: hsa:491

    STRING: 9606.ENSP00000324172

    UniGene: Hs.268942