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ATP4B Antibody

  • 货号：
    CSB-PA017108
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA017108(ATP4B Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA017108(ATP4B Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse pancreas tissue, Primary antibody: CSB-PA017108(ATP4B Antibody) at dilution 1/250 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

产品详情

  • Uniprot No.：
    P51164
  • 基因名：
  • 别名：
    Gastric H(+)/K(+) ATPase subunit beta antibody; ATP4B antibody; ATP4B_HUMAN antibody; ATP6B antibody; ATPase H+/K+ exchanging beta polypeptide antibody; ATPase H+/K+ transporting beta polypeptide antibody; Gastric H K ATPase catalytic subunit antibody; Gastric H(+)/K(+) ATPase subunit beta antibody; Gastric H+/K+ ATPase beta subunit antibody; Gastric hydrogen potassium ATPase antibody; Gastric hydrogen potassium ATPase beta antibody; Hydrogen/potassium exchanging ATPase 4B antibody; OTTHUMP00000178856 antibody; Parietal cell antigen antibody; Potassium transporting ATPase beta chain antibody; Potassium transporting ATPase subunit beta antibody; Potassium-transporting ATPase subunit beta antibody; Proton pump antibody; Proton pump beta chain antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human ATP4B
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump. Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle.
  • 基因功能参考文献：
    1. these findings demonstrated that a decrease in pHi, caused by H+/K+-ATPase inhibition induced by BMT-1, triggered the dysfunction of the mitochondria resulting in the apoptosis of MM cells PMID: 24700195
    2. Downregulation of ATP4B gene is associated with gastric cancer. PMID: 23317218
    3. BCL-2 inhibits formation of reactive oxygen species. PMID: 11865975
    4. Content of the beta1 subunit of sodium potassium pump in resistance trained control subjects was 33% higher in trained compared to untrained leg, and 47% higher in trained compared to untrained leg in diabetics. PMID: 14685860
    5. Thus prolonged exhaustive exercise impaired each of the maximal in vitro Na+-K+-ATPase activity, Ca2+ release, and Ca2+ uptake rates. PMID: 15155714
    6. Use of fold recognition methods enables the prediction that a C-terminal domain of the beta subunits of Na,K-ATPase and H,K-ATPase has an immunoglobulin-like fold, which resembles cell adhesion molecules. PMID: 19694409

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  • 亚细胞定位：
    Apical cell membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    X(+)/potassium ATPases subunit beta family
  • 数据库链接：

    HGNC: 820

    OMIM: 137217

    KEGG: hsa:496

    STRING: 9606.ENSP00000334216

    UniGene: Hs.434202