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ATP6V0D1 Antibody

  • 货号：
    CSB-PA002390ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA002390ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ATP6V0D1 Polyclonal antibody
  • Uniprot No.：
    P61421
  • 基因名：
  • 别名：
    32 kDa accessory protein antibody; ATP6D antibody; ATP6DV antibody; ATP6V0D1 antibody; ATPase H+ transporting lysosomal (vacuolar proton pump) member D antibody; ATPase H+ transporting lysosomal 38kD V0 subunit d antibody; ATPase H+ transporting lysosomal 38kDa V0 subunit d1 antibody; ATPase H+ transporting lysosomal V0 subunit d1 antibody; H(+) transporting two sector ATPase subunit D antibody; p39 antibody; V ATPase 40 KDa accessory protein antibody; V ATPase AC39 subunit antibody; V ATPase subunit d 1 antibody; V ATPase subunit D antibody; V-ATPase 40 kDa accessory protein antibody; V-ATPase AC39 subunit antibody; V-ATPase subunit d 1 antibody; V-type proton ATPase subunit d 1 antibody; VA0D1_HUMAN antibody; Vacuolar ATP synthase subunit d 1 antibody; Vacuolar proton pump subunit d 1 antibody; VATX antibody; VMA 6 antibody; VMA6 antibody; VPATPD antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human V-type proton ATPase subunit d 1 protein (1-351AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Subunit of the integral membrane V0 complex of the lysosomal proton-transporting V-type ATPase (v-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium.
  • 基因功能参考文献：
    1. The secondary structures of d1 and d2 subunits were highly similar, but the relative stability against thermal stress was higher for d1 than d2. PMID: 24631925
    2. two adjacent enhancers inside the first intron of the neighboring (1.4 kb downstream) ATPase gene (ATP6V0D1) modulate the human AgRP promoter with profound spatiotemporal variation PMID: 19285986
    3. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia PMID: 19165527
  • 亚细胞定位：
    Membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane.
  • 蛋白家族：
    V-ATPase V0D/AC39 subunit family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 13724

    OMIM: 607028

    KEGG: hsa:9114

    STRING: 9606.ENSP00000290949

    UniGene: Hs.106876