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ATP8A1 Antibody

  • 货号：
    CSB-PA002416GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y2Q0
  • 基因名：
    ATP8A1
  • 别名：
    ATP8A1 antibody; ATPIAPhospholipid-transporting ATPase IA antibody; EC 7.6.2.1 antibody; ATPase class I type 8A member 1 antibody; Chromaffin granule ATPase II antibody; P4-ATPase flippase complex alpha subunit ATP8A1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ATP8A1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells.
  • 基因功能参考文献：
    1. Knockdown of ATP8A1 (a recycling endosome phosphatidlyserine-flippase) suppresses nuclear localization of YAP and YAP-dependent transcription. ATP8A1 knockdown increases the phosphorylated (activated) form of Lats1 that phosphorylates and inactivates YAP. PMID: 29093443
    2. The increased level of intracellular ATP8A1 protein attenuated the inhibitor role of miR-140-3p in the growth and mobility of NSCLC cell. PMID: 26415732
    3. Depletion of ATP8A1 impaired the asymmetric transbilayer distribution of phosphatidylserine in recycling endosomes, dissociated EHD1 from recycling endosomes, and generated aberrant endosomal tubules that appear resistant to fission. PMID: 25595798
    4. the phospholipid flippase complex of ATP8A1 and CDC50A proteins has a role in cell migration PMID: 23269685
    5. APLT has a role in macrophage-induced nitrosylation/oxidation plays an important role in cell clearance PMID: 17229723

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  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Multi-pass membrane protein. Cytoplasmic granule. Cell membrane. Endoplasmic reticulum. Golgi apparatus.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily
  • 组织特异性：
    Found in most adult tissues except liver, testis and placenta. Most abundant in heart, brain and skeletal muscle. Also detected in fetal tissues. Isoform 1 is only detected in brain, skeletal muscle and heart and is the most abundant form in skeletal musc
  • 数据库链接：

    HGNC: 13531

    OMIM: 609542

    KEGG: hsa:10396

    STRING: 9606.ENSP00000371084

    UniGene: Hs.435052