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AURKAIP1 Antibody

  • 货号：
    CSB-PA794202
  • 规格：
    ￥1100
  • 图片：
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human testis tissue, Primary antibody: CSB-PA794202(AURKAIP1 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

产品详情

  • Uniprot No.：
    Q9NWT8
  • 基因名：
    AURKAIP1
  • 别名：
    28S ribosomal protein S38 antibody; AIP antibody; AKIP_HUMAN antibody; AURKA interacting protein antibody; AURKA-interacting protein antibody; AURKAIP 1 antibody; Aurkaip1 antibody; Aurora A kinase interacting protein antibody; Aurora kinase A interacting protein 1 antibody; Aurora kinase A-interacting protein antibody; FLJ20608 antibody; mitochondrial antibody; MRP-S38 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human AURKAIP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.
  • 基因功能参考文献：
    1. Encodes a mitochondrial protein PMID: 22356826
    2. Aurora-A protein increased in stomach cancer cells in response to cisplatin and was degraded upon combined treatment with capsaicin with cisplatin. PMID: 21932983
    3. Results describe the identification of a novel negative regulator of Aurora-A, named AIP (Aurora-A kinase Interacting Protein). PMID: 12244051
    4. Phe31Ile polymorphism in Aurora A may be a genetic modifier for developing breast carcinoma. PMID: 15271856
    5. We propose that AURKAIP1 might function upstream of the Az1 by enhancing the binding affinity of Az1 to Aurora-A to promote recognition, targeting to proteasome and subsequent degradation. PMID: 17452972
    6. AKURA phosphorylation of AIP and stabilization of the enzyme-substrate complex are reported. PMID: 17957726
    7. GSK-3beta modulates the early mitotic Aurora-A level through binding and phosphorylating AIP. PMID: 18391981
    8. Plk1 controls Aurora A localization and function by regulating cellular levels of hBora. PMID: 18521620
    9. Aurora A is necessary for the maintenance of the mitotic delay induced in response to microtubule-perturbing agents. PMID: 19221504

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  • 亚细胞定位：
    Mitochondrion. Nucleus.
  • 蛋白家族：
    Mitochondrion-specific ribosomal protein mS38 family
  • 组织特异性：
    Ubiquitously expressed and especially highly expressed in heart, skeletal muscle and testis.
  • 数据库链接：

    HGNC: 24114

    OMIM: 609183

    KEGG: hsa:54998

    STRING: 9606.ENSP00000319778

    UniGene: Hs.632515