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  4. AVEN Antibody

AVEN Antibody

  • 货号：
    CSB-PA403881
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA403881(AVEN Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA403881(AVEN Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9NQS1
  • 基因名：
    AVEN
  • 别名：
    1700013A01Rik antibody; 1700056A21Rik antibody; Apoptosis caspase activation inhibitor antibody; AVEN antibody; AVEN_HUMAN antibody; Cell death regulator Aven antibody; mAven L antibody; mAven S antibody; MGC124011 antibody; OTTMUSP00000016129 antibody; PDCD12 antibody; Programmed cell death 12 antibody; RP23-52C15.2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human AVEN
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Protects against apoptosis mediated by Apaf-1.
  • 基因功能参考文献：
    1. AVEN and BIRC6 are inhibited by combination therapy of miR-30e and proanthocyanidin in glioblastoma stem cells PMID: 27388765
    2. The Aven RGG/RG motif bound G4 structures within the coding regions of the MLL1 and MLL4 mRNAs increasing their polysomal association and translation, resulting in the induction of transcription of leukemic genes. PMID: 26267306
    3. the expression of Aven is regulated by the Akt signaling pathway through cathepsin D activity, which contributes to the sensitivity of cancer cells to chemotherapeutic agents. PMID: 25573060
    4. The findings implicate Aven in ATR-Chk1 signalling and point towards Chk1 inhibition as a strategy to sensitize human osteosarcomas to chemotherapy. PMID: 25757065
    5. Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms. PMID: 22751129
    6. a model of Aven activation by which its N-terminal inhibitory domain is removed by CathD-mediated proteolysis, thereby unleashing its cytoprotective function. PMID: 22388353
    7. The results suggest that deregulation of the expression of the apoptosis inhibitor Aven may be related to male factor infertility. PMID: 21718987
    8. the expression level of aven mRNA in de novo AML patients obviously increases PMID: 20030919
    9. Results suggest that the regulation of Exportin-1/CRM1-dependent nucleocytoplasmatic traffic of Aven could modulate its ability to influence cell cycle progression. PMID: 20935510
    10. Aven expression was found to be higher in patients >or=10 years old or <1 year, and with unfavorable cytogenetic abnormalities. It was also significantly higher in relapsed patients in the standard-risk group and an independent poor prognostic factor. PMID: 16388850
    11. point mutation observed by transcriptome sequencing of malignant pleural mesothelioma tumors PMID: 18303113
    12. These results identify Aven as a new ATM activator and describe a positive feedback loop operating between Aven and ATM; in aggregate, these findings place Aven, a known apoptotic inhibitor, as a critical transducer of the DNA-damage signal. PMID: 18571408

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  • 亚细胞定位：
    Endomembrane system; Peripheral membrane protein. Note=Associated with intracellular membranes.
  • 组织特异性：
    Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart, skeletal muscle, liver, kidney and pancreas.
  • 数据库链接：

    HGNC: 13509

    OMIM: 605265

    KEGG: hsa:57099

    STRING: 9606.ENSP00000306822

    UniGene: Hs.555966