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AZI2 Antibody

  • 货号：
    CSB-PA003368
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HepG2 cells using Nap1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9H6S1
  • 基因名：
    AZI2
  • 别名：
    5 azacytidine induced protein 2 antibody; 5-azacytidine-induced protein 2 antibody; AA410145 antibody; AZ2 antibody; AZI2 antibody; AZI2_HUMAN antibody; MGC112644 antibody; Nak associated protein 1 antibody; Nak-associated protein 1 antibody; NAP1 antibody; NF kappa B activating kinase associated protein 1 antibody; NF-kappa-B-activating kinase-associated protein 1 antibody; TILP antibody; TILP(S) antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human Nap1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1.
  • 基因功能参考文献：
    1. These results define NAK-associated protein 1 (NAP1) as an activator of IkappaB kinase-related kinases and suggest that the NAK-NAP1 complex may protect cells from TNF-alpha-induced apoptosis by promoting NF-kappaB activation. PMID: 14560022
    2. Both the cytoplasmic and TLR3-mediated dsRNA recognition pathways converge upon NAP1 for the activation of the IRF-3 and IFN-beta promoter. PMID: 17142768
    3. the spatiotemporal mobilization of TICAM-1 in response to dsRNA and the formation of the TICAM-1 speckles containing RIP1 and NAP1 are important for the activation of the TLR3-TICAM-1 pathway. PMID: 17982077
  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Widely expressed. Abundant expression seen in the pancreas and testis.
  • 数据库链接：

    HGNC: 24002

    OMIM: 609916

    KEGG: hsa:64343

    STRING: 9606.ENSP00000419371

    UniGene: Hs.706676