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Abcb4 Antibody

  • 货号：
    CSB-PA001050LA01MO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Abcb4 Polyclonal antibody
  • Uniprot No.：
    P21440
  • 基因名：
    Abcb4
  • 别名：
    Abcb4 antibody; Mdr2 antibody; Pgy-2 antibody; Pgy2 antibody; Phosphatidylcholine translocator ABCB4 antibody; EC 7.6.2.1 antibody; ATP-binding cassette sub-family B member 4 antibody; Multidrug resistance protein 2 antibody; Multidrug resistance protein 3 antibody; P-glycoprotein 2 antibody; P-glycoprotein 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse
  • 免疫原：
    Recombinant Mouse Phosphatidylcholine translocator ABCB4 protein (352-708AA)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Abcb4 Antibody (CSB-PA001050LA01MO)，的标记方式是Non-conjugated。对于Abcb4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA001050LB01MO Abcb4 Antibody, HRP conjugated ELISA
    FITC CSB-PA001050LC01MO Abcb4 Antibody, FITC conjugated
    Biotin CSB-PA001050LD01MO Abcb4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi between hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts. Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes. Required for proper phospholipid bile formation. Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner. May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane. In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts. Does not confer multidrug resistance.
  • 基因功能参考文献：
    1. When looking at the gender-specific response to corticosterone treatment, male MDR2KO mice tended to have a more pronounced reversal of liver fibrosis than females treated with corticosterone PMID: 29125588
    2. reduced ABCB4 expression predisposes to extrahepatic biliary atresia PMID: 28355206
    3. Findings imply a close link between Mdr2 (-/-) -associated tumorigenesis and perturbation of these biological processes and suggest potential extrahepatic functions of Mdr2. PMID: 26542370
    4. The antifibrotic effects of rapamycin, everolimus, captopril and irbesartan seen in other models of fibrosis were not replicated in the Mdr2(-/-) model of liver fibrosis. PMID: 24517519
    5. A new Mdr2(-/-) mouse model of sclerosing cholangitis with rapid fibrosis progression, early-onset portal hypertension, and liver cancer. PMID: 25478810
    6. Glyceryl trinitrate improves hepatocyte engraftment and correction of metabolic disease in mdr2 (-/-) mice. PMID: 25340599
    7. nsulin-like growth factor 1 enhances bile-duct proliferation and fibrosis in Abcb4(-/-) mice. PMID: 23416526
    8. Data indicate that Abcb4-knockout mice displayed significantly (P<0.001) lower plasma glucose concentrations than corresponding wild-type controls. PMID: 22982378
    9. Flippase ATP8B1 and the floppase ABCB4 have complementary functions in maintaining canalicular membrane integrity. PMID: 21820390
    10. The induction of Mdr2 mRNA and Mdr2 protein levels by fibrates is mediated by PPARalpha, while the induction of Mdr1a / 1b in vivo probably reflects a secondary phenomenon related to chronic PPARalpha activation. PMID: 12381268
    11. spontaneous gallstone formation occurs in Mdr2 (Abcb4) knockout mice that are characterized by phospholipid-deficient bile PMID: 14752830
    12. Bile duct proliferation in Mdr2(-/-) mice enhances cholehepatic shunting of bile salts, which is associated with a disproportionally high bile flow but does not affect bile salt synthesis. PMID: 15910498
    13. MDR2 expression is required for ABCG5- and ABCG8-mediated biliary sterol secretion. Inactivation of MDR2 markedly attenuated the reduction in fractional sterol absorption associated with ABCG5, ABCG8 overexpression PMID: 15930516
    14. Mdr2 (+/-) mice have diminished susceptibility to MCD diet-induced NASH, which is associated with a relative decrease in PEMT activity and increased SAM:SAH ratios. PMID: 16376450
    15. 24-norUrsodeoxycholic acid ameliorates sclerosing cholangitis in Mdr2 deficient mice. PMID: 16472600
    16. Mdr2 seems not to be involved in the protection of the fetus from teratogens. PMID: 17440929
    17. Multiple genes regulating inflammation and fibrosis not previously linked to Abcb4 deficient cholangitis are identified as being differentially transcribed in Abcb4 deficient livers, where they contribute to the pathogenesis of liver tissue pathology. PMID: 17852852

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Membrane raft. Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle.
  • 蛋白家族：
    ABC transporter superfamily, ABCB family, Multidrug resistance exporter (TC 3.A.1.201) subfamily
  • 组织特异性：
    Expressed in the liver (at protein level). Expressed in adrenal, liver, muscle, spleen and heart. Expressed in multidrug-resistant cell lines.
  • 数据库链接：

    KEGG: mmu:18670

    STRING: 10090.ENSMUSP00000003717

    UniGene: Mm.297825