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Arg2 Antibody

  • 货号：
    CSB-PA002006LA01MO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Arg2 antibody at 10µg/ml + Jurkat whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 39 kDa
      Observed band size: 39 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Arg2 Polyclonal antibody
  • Uniprot No.：
    O08691
  • 基因名：
    Arg2
  • 别名：
    Arg2Arginase-2 antibody; mitochondrial antibody; EC 3.5.3.1 antibody; Arginase II antibody; Kidney-type arginase antibody; Non-hepatic arginase antibody; Type II arginase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse, Human
  • 免疫原：
    Recombinant Mouse Arginase-2, mitochondrial protein (23-354AA)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Arg2 Antibody (CSB-PA002006LA01MO)，的标记方式是Non-conjugated。对于Arg2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA002006LB01MO Arg2 Antibody, HRP conjugated ELISA
    FITC CSB-PA002006LC01MO Arg2 Antibody, FITC conjugated
    Biotin CSB-PA002006LD01MO Arg2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction. Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling. Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity.
  • 基因功能参考文献：
    1. The possibility that the Gas6-Mer-PI3K/Akt-STAT1-LXR-Arg2 pathway plays an essential role for resolving inflammatory response in acute lung injury. PMID: 27406916
    2. ARG2 which hydrolyzes arginine into ornithine and urea, is induced upon obesity, and silencing or loss of ARG2 markedly suppresses pancreatic ductal adenocarcinoma. PMID: 28808255
    3. the finding of this study is that ARG2 contributes to the immune evasion of H. pylori by restricting M1 macrophage activation and polyamine metabolism. PMID: 27074721
    4. Arginase II expression is reduced in aortic endothelial cells and macrophages following PARP-1 knockout. PMID: 27757983
    5. This study shows for the first time that neurovascular injury after retinal ischemia/reperfusion is mediated through increased expression of Arginase 2. PMID: 27882947
    6. Arg2 KO female (not male) mice are protected from age-associated glucose intolerance and reveal greater glucose induced-insulin release, larger islet size and beta-cell mass, and more proliferative and less apoptotic beta-cells compared with the age-matched WT controls. Arg2 is mainly expressed in acinar cells and is upregulated with aging, which enhances p38 MAPK activation and release of TNF-alpha. PMID: 28356309
    7. arginase 2 impairs endothelial autophagy independently of the L-arginine ureahydrolase activity through activation of RPS6KB1 and inhibition of PRKAA, which is implicated in atherogenesis PMID: 25484082
    8. high fat diet enhanced arginase-II expression/activity and p38mapk activity, which was associated with eNOS-uncoupling as revealed by decreased nitric oxide PMID: 25034973
    9. Arg-II, p38, and S6K1 form a positive circuit which regulates endothelial senescence and cardiovascular aging. PMID: 25635535
    10. Arginase 2 deletion prevents hyperoxia-induced retinal vascular injury by preventing NOS uncoupling resulting in decreased reactive oxygen species formation and increased nitric oxide bioavailability. PMID: 25375125
    11. ERK2 and p38 regulate arginase II induction in LPS-stimulated macrophages, but iNOS induction by LPS is dependent on p38 activation PMID: 25451938
    12. OxLDL triggers retrograde translocation of arginase2 in aortic endothelial cells via ROCK and mitochondrial processing peptidase. PMID: 24903103
    13. Suggest that retinal arginase is involved in the hyperoxia-induced neuronal degeneration in the OIR model, through the regulation of polyamine metabolism. PMID: 24556690
    14. miR155-induced repression of Arg2 expression is critical for the ability of dendritic cells to drive T cell activation by controlling arginine availability in the extracellular environment. PMID: 25009204
    15. HDAC2 is a critical regulator of Arg2 expression and thereby endothelial nitric oxide and endothelial function. PMID: 24833798
    16. Arginase inhibition mediates renal tissue protection in diabetic nephropathy by an eNOS-dependent mechanism and has an eNOS-independent effect on kidney macrophage recruitment. PMID: 23760286
    17. ROCK 2, p38 MAPK and arginase play key roles in diabetes-induced impairment of corpora cavernosa relaxation. PMID: 23566117
    18. Arg-II promotes mitochondrial dysfunction leading to VSMC senescence/apoptosis through complex positive crosstalk among S6K1-JNK, ERK, p66Shc, and p53, contributing to atherosclerotic vulnerability phenotype. PMID: 23832324
    19. Studied thoracic aorta from ApoE-/- mice, and found the high-cholesterol diet (HCD) induced an increase in arginase activity, a decrease in NO release and an increase in reactive oxygen species generation that was reversed by treatment with PG. PMID: 23443634
    20. Arginase II is upregulated in aortic vessels of aged mice and contributes to decreased nitric oxide generation and increased reactive oxygen species production via endothelial nitric oxide synthase uncoupling. PMID: 22854495
    21. A novel mechanism has been uncovered for mutual positive regulation between S6K1 and Arg-II in endothelial inflammation and aging. PMID: 22928666
    22. IL-13 contributes to the development of pulmonary hypertension via an IL-13receptor alpha2-arginase 2-dependent pathway. PMID: 23125252
    23. inhibition of Arg2 increases L-arginine levels, diminishes ROS production and ameliorates nitrate tolerance PMID: 22288373
    24. In diabetes models, kidney Arg2 increases as diabetes develops (but not in diabetic Arg2-deficient mice). Increase in kidney arginase activity is associated with loss of renal function; such function loss is not seen in diabetic Arg2-deficient mice. PMID: 21926276
    25. Data suggest that the in vivo source for the essential urea utilized by H. pylori urease is neither bacterial arginase nor host arginase II; instead, either residual host arginase I or agmatinase is probably responsible. PMID: 21876618
    26. data implicate Arg2 in neurodegeneration during retinopathy of prematurity; deletion significantly improves neuronal survival and function, possibly through the regulation of mitochondrial membrane permeability mediated apoptosis during retinal ischemia PMID: 21811615
    27. a high fat diet affects arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice PMID: 21151916
    28. Helicobacter infection induces Arg2 (but not Arg1) in gastric lamina propria macrophages. PMID: 21296975
    29. Delineate a clearer path from OxLDL through the endothelial cell LOX-1 receptor, RhoA, and ROCK, to the activation of arginase II, downregulation of NO, and vascular dysfunction in atherosclerosis. PMID: 21130456
    30. Data suggest that arginase II present in the small intestinal mucosa has the role of providing ornithine for citrulline synthesis. PMID: 20978229
    31. arginase II deficiency leads to a better CBF recovery after TBI and implicates arginase II in hemodynamic processes. PMID: 20372170
    32. Studies implicate Arg2 in the immune evasion of H. pylori by causing intracellular depletion of l-arginine and thus reduction of NO-dependent bactericidal activity. PMID: 20097867
    33. Arginase II expression in mouse embryonic development PMID: 12049781
    34. Arginase II mRNA levels and enzyme activity in macrophages from Trypanosoma brucei brucei-infected mice are higher in susceptible BALB/c mice compared with resistant C57BL/6 mice. PMID: 15128819
    35. Variations of the levels of OAT protein and arginase II mRNA and protein were strongly correlated with testosteronemia. PMID: 15539552
    36. AII was expressed in the cortex and the outer stripe of outer medulla, urea was produced mainly in the proximal tubules, the 38-kDa AII protein was more abundant in the mitochondria than the cytosol, and AII was three-fold higher in females than males PMID: 15616821
    37. Arg2 is an anti-inflammatory target of liver X receptor in macrophages. PMID: 16943198
    38. Endothelial cell mitochondrial arginase II regulates NO production, vascular endothelial function, and vascular stiffness by modulating NOS-3 activity. PMID: 17827260
    39. These results suggested that an increase in arginase may lead to decreased availability of arginine for nitric oxide synthase and may contribute to the remodeling of the lung. PMID: 17890324
    40. arginase II plays a critical role in the pathophysiology of cholesterol-mediated endothelial dysfunction PMID: 18309100
    41. Lack of arginase II in the TRAMP model seems to speed up the tumor progression process leading to a more aadvanced cancer state in these mice. PMID: 18663728

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  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Arginase family
  • 数据库链接：

    KEGG: mmu:11847

    STRING: 10090.ENSMUSP00000021550

    UniGene: Mm.3506