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BAAT Antibody

  • 货号：
    CSB-PA002523GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q14032
  • 基因名：
    BAAT
  • 别名：
    FLJ20300 antibody; BAAT antibody; BAAT_HUMAN antibody; BACAT antibody; BAT antibody; Bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase) antibody; Bile acid CoA:amino acid N acyltransferase antibody; Bile acid Coenzyme A amino acid N acyltransferase glycine N choloyltransferase antibody; Bile acid Coenzyme A: amino acid N acyltransferase antibody; Bile acid-CoA:amino acid N-acyltransferase antibody; Glycine N choloyltransferase antibody; Glycine N-choloyltransferase antibody; Long chain fatty acyl CoA hydrolase antibody; Long-chain fatty-acyl-CoA hydrolase antibody; MGC104432 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human BAAT
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine. More than 95% of the BAs are N-acyl amidates with glycine and taurine. Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism. This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption. May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.
  • 基因功能参考文献：
    1. BAAT polymorphisms might not be associated with anti-tuberculosis drug-induced hepatotoxicity in the Chinese population PMID: 27155186
    2. These results indicate that even small changes in the carboxy terminus of BAAT can have significant effects on activity and substrate specificity PMID: 27230263
    3. Case Report: mmunostaining may facilitate diagnosis in bile-acid amidation defects in bile acid-CoA: amino acid N-acyltransferase deficiency. PMID: 22783059
    4. there is an essential catalytic triad within hBAT consisting of Cys-235, His-362, and Asp-328 with Cys-235 serving as the probable nucleophile and thus the site of covalent attachment of the bile acid molecule PMID: 12239217
    5. Familial hypercholanemia in Amish individuals is associated with mutations in tight junction protein 2 (encoded by TJP2, also known as ZO-2) and bile acid Coenzyme A: amino acid N-acyltransferase (encoded by BAAT). PMID: 12704386
    6. cytosolic BACAT enzyme may play important roles in protection against toxicity by accumulation of unconjugated bile acids and non-esterified very long-chain fatty acids PMID: 12810727
    7. hBAAT and rBaat are peroxisomal enzymes present in undetectable amounts in the cytosol. Unconjugated or deconjugated bile salts returning to the liver need to shuttle through the peroxisome before reentering the enterohepatic circulation. PMID: 17256745
    8. identification of 3 novel SNPs, 147C>T in exon 2 (silent), 602G>C in exon 3 (Arg201Pro) & 1134C>T in exon 4 (silent), in the BAAT gene by resequencing the entire coding region and the exon-intron junctions of 100 Japanese individuals PMID: 17495420
    9. Data show that dose-response inactivation by 4HNE (4-hydroxynonenal) of hBAT (human bile acid CoA:amino acid N-acyltransferase) and CKBB (cytosolic brain isoform of creatine kinase) is associated with site-specific modifications. PMID: 18793185

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  • 相关疾病：
    Familial hypercholanemia (FHCA)
  • 亚细胞定位：
    Cytoplasm, cytosol. Peroxisome.
  • 蛋白家族：
    C/M/P thioester hydrolase family
  • 组织特异性：
    Expressed in liver, gallbladder mucosa and pancreas.
  • 数据库链接：

    HGNC: 932

    OMIM: 602938

    KEGG: hsa:570

    STRING: 9606.ENSP00000259407

    UniGene: Hs.284712