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BACE2 Antibody

  • 货号：
    CSB-PA002525GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y5Z0
  • 基因名：
    BACE2
  • 别名：
    ALP 56 antibody; ALP56 antibody; Asp 1 antibody; ASP1 antibody; ASP21 antibody; Aspartic Like Protease 56kDa antibody; Aspartic-like protease 56 kDa antibody; Aspartyl protease 1 antibody; BACE 2 antibody; Bace2 antibody; BACE2_HUMAN antibody; Beta Secretase 2 antibody; Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2 antibody; Beta-secretase 2 antibody; Beta-site amyloid precursor protein cleaving enzyme 2 antibody; Beta-site APP cleaving enzyme 2 antibody; Down region aspartic protease antibody; Downs Syndrome Region Aspartic Protease antibody; DRAP antibody; Memapsin 1 antibody; Memapsin-1 antibody; Membrane associated aspartic protease 1 antibody; Membrane-associated aspartic protease 1 antibody; Theta-secretase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human BACE2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells.
  • 基因功能参考文献：
    1. RNA-seq evidence of biallelic expression of BACE2 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of BACE2 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals. PMID: 27100087
    2. Data identified two novel genome-wide significant associations: 2-h plasma glucose and HKDC1, and fasting C-peptide and BACE2. PMID: 23903356
    3. BACE2 cleaves the integral membrane form of PMEL within the juxtamembrane domain, releasing the PMEL luminal domain into endosomal precursors for the formation of amyloid fibrils and downstream melanosome morphogenesis. PMID: 23754390
    4. BACE2 overexpression in cultured cells was found to lower net amyloid ss-protein levels. PMID: 22986058
    5. The BACE2 distal promoter contains an activating cis-regulatory element that is responsive to Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. PMID: 20494980
    6. All these data point to a role for BACE2 in the IRbeta trafficking and insulin signaling. In conclusion, BACE2 is hereby presented as an important enzyme in beta-cell function. PMID: 20943756
    7. Trransgenic BACE2 mice show increased anxiety-like behaviour along with increased numbers of noradrenergic neurones in the locus coeruleus. PMID: 19840121
    8. BACE has a loose substrate specificity and that the substrate recognition site in BACE extends over several amino acids PMID: 11741910
    9. Specificity and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity PMID: 12093293
    10. the enzymatic properties of BACE2 were analyzed, including substrate specificity and pH range PMID: 12423367
    11. A novel aspartic protease gene, ALP56, is up-regulated in human breast cancer. ALP56 may be a useful target molecule in breast cancer treatment. PMID: 12611455
    12. antagonistic effect with beta-site amyloid precursor protein-cleaving enzyme 1 on beta-amyloid peptide production in cells PMID: 12801932
    13. Analysis revealed a 2.6-fold increase in BACE-2 mRNA levels in Down syndrome brains compared to the control group; increased secretion of BACE-2 by cultured fibroblasts and neural stem cells from Down syndrome patients was noted PMID: 12895444
    14. Chromosome 21 BACE2 haplotype associates with Alzheimer's disease PMID: 16023140
    15. the crystal structure of mature BACE2 in complex with a hydroxyethylamine transition-state mimetic inhibitor at 3.1 angstroms resolution was presented. PMID: 16305800
    16. Data characterize the human beta-secretase 2 (BACE2) 5'-flanking region. PMID: 16757812
    17. BACE2is not involved in the Alzheimer dissease(AD)pathogenesis of Down syndrome (DS) patients; instead, therapeutic interventions that potentiate BACE2 may prevent AD pathogenesis. PMID: 16816112
    18. The expression levels of BACE2 was comparable between DS and controls in fetal brain and in adult brain. PMID: 18163181
    19. study found no association between three BACE2 polymorphisms and sporadic Alzheimer's disease in the Chinese Han population even after statistical adjustment for age, gender and APOE epsilon 4 status PMID: 19124009

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome.
  • 蛋白家族：
    Peptidase A1 family
  • 组织特异性：
    Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed
  • 数据库链接：

    HGNC: 934

    OMIM: 605668

    KEGG: hsa:25825

    STRING: 9606.ENSP00000332979

    UniGene: Hs.43047