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BCAS3 Antibody

  • 货号：
    CSB-PA872507ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA872507ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) BCAS3 Polyclonal antibody
  • Uniprot No.：
    Q9H6U6
  • 基因名：
    BCAS3
  • 别名：
    1500019F07Rik antibody; 2610028P08Rik antibody; AU021018 antibody; BC028339 antibody; BCAS3 antibody; BCAS3_HUMAN antibody; Breast carcinoma-amplified sequence 3 antibody; FLJ20128 antibody; GAOB1 antibody; K20D4 antibody; MAAB antibody; Maab1 protein antibody; MGC4973 antibody; rudhira antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Breast carcinoma-amplified sequence 3 protein (689-928AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation. Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy. Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures.
  • 基因功能参考文献：
    1. Real-time PCR validated that up-regulation of sulphiredoxin 1 homolog (SRXN1), hemeoxygenase 1 (HMOX1), and breast carcinoma amplified sequence 3 (BCAS3) were consistently modulated. PMID: 21742584
    2. role for MTA1-BCAS3 pathway in promoting cancerous phenotypes in breast tumor cells PMID: 16617102
    3. BCAS3 overexpression in hormone receptor-positive premenopausal breast cancer seemed to be associated with impaired responses to tamoxifen PMID: 16855396
    4. Physically associated with histone H3 and histone acetyltransferase complex protein P/CAF (p300/CBP-associated factor) and possesses histone acetyltransferase activity. PMID: 17505058
    5. BCAS3 is mis-expressed in brain tumors and could serve as a human ES cell and tumor marker PMID: 18030336

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  • 相关疾病：
    A chromosomal aberration involving BCAS3 has been found in some breast carcinoma cell lines. Translocation t(17;20)(q23;q13) with BCAS4.
  • 亚细胞定位：
    Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Preautophagosomal structure.
  • 蛋白家族：
    BCAS3 family
  • 组织特异性：
    Expressed in stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leukocyte and mammary epithelial cells. Expressed in undifferentiated ES cells. Expre
  • 数据库链接：

    HGNC: 14347

    OMIM: 607470

    KEGG: hsa:54828

    STRING: 9606.ENSP00000375067

    UniGene: Hs.655028