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BCAT2 Antibody

  • 货号：
    CSB-PA002601ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: BCAT2 antibody at 14µg/ml + 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 45, 34 kDa
      Observed band size: 34 kDa
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA002601ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA002601ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) BCAT2 Polyclonal antibody
  • Uniprot No.：
    O15382
  • 基因名：
    BCAT2
  • 别名：
    BCAM antibody; BCAT 2 antibody; BCAT(m) antibody; BCAT2 antibody; BCAT2_HUMAN antibody; BCATM antibody; BCT2 antibody; Branched chain aminotransferase 2; mitochondrial antibody; Branched-chain-amino-acid aminotransferase antibody; ECA40 antibody; mitochondrial antibody; Placental protein 18 antibody; PP18 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Branched-chain-amino-acid aminotransferase, mitochondrial protein (20-200AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.
  • 基因功能参考文献：
    1. identification of a peroxide-sensitive redox switch at the CXXC motif PMID: 12119021
    2. Studies of ketimine and pyridoxamine phosphate forms of BCAT@ reaction intermediates reveal substrate specificity for L-branched chain amino acids via a group of hydrophobic residues that form three hydrophobic surfaces and lock the side chain in place. PMID: 12269802
    3. role of cysteine residues in the regulatory CXXC motif PMID: 15182179
    4. ption of the CXXC center results in altered substrate orientation and deprotonation of the amino group of pyridoxamine 5'-phosphate, which inhibits catalysis PMID: 17050531
  • 亚细胞定位：
    [Isoform A]: Mitochondrion.; [Isoform B]: Cytoplasm.
  • 蛋白家族：
    Class-IV pyridoxal-phosphate-dependent aminotransferase family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 977

    OMIM: 113530

    KEGG: hsa:587

    STRING: 9606.ENSP00000322991

    UniGene: Hs.512670