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BIRC7 Antibody

  • 货号：
    CSB-PA003248
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COLO205 cells using ML-IAP Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q96CA5
  • 基因名：
    BIRC7
  • 别名：
    Baculoviral IAP repeat containing 7 antibody; Baculoviral IAP repeat containing protein 7 antibody; Baculoviral IAP repeat-containing protein 7 antibody; BIRC 7 antibody; birc7 antibody; BIRC7_HUMAN antibody; KIAP antibody; Kidney inhibitor of apoptosis protein antibody; Livin antibody; Livin inhibitor of apotosis antibody; Melanoma inhibitor of apoptosis protein antibody; ML IAP antibody; ML-IAP antibody; MLIAP antibody; RING finger protein 50 antibody; RNF 50 antibody; RNF50 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ML-IAP.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.
  • 基因功能参考文献：
    1. The overexpression of PTEN concomitant with Livin gene silencing was confirmed as a feasible and effective in vitro and in vivo gene modulation method, which may represent a potential therapeutic strategy for the treatment of Gastric Cancer. PMID: 29436592
    2. Livin overexpression not only significantly inhibited RCC cell apoptosis and increased cell viability, but completely reversed the si-CCAT1-mediated repression of cell viability PMID: 28470345
    3. our results revealed that Livin induced EMT through the activation of the p38/GSK3beta pathway, which in turn promoted the progression and metastasis of breast cancer, especially for triple-negative breast cancer (TNBC) PMID: 29039608
    4. our results suggest that siRNA-mediated Livin knockdown enhanced the chemosensitivity of the three head and neck squamous cell carcinoma cell lines to cisplatin, 5-FU and docetaxel. PMID: 28440463
    5. Livin is specifically over-expressed in adrenocortical carcinoma. PMID: 28030838
    6. Further experiments confirmed the induction of cell apoptosis and suppression of cell proliferation by anti-MM scFv-tP in LiBr cells, along with efficient silence of Livin gene both in vitro and in vivo. Altogether, our findings provide a feasible approach to transport Livin small interfering RNA to malignant melanoma cells which would be a new therapeutic strategy for combating malignant melanoma PMID: 28459204
    7. MicroRNA-214 inhibits the osteogenic differentiation of human osteoblasts through the direct regulation of BIRC7. PMID: 28109866
    8. the results of the present study suggested that Livin may enhance tumorigenesis by modulating the mitogenactivated/Akt signaling pathways in human HSCC. PMID: 27175933
    9. Positive BIRC7 expression and negative KLF4 expression are associated with the progression of PDAC and poor prognosis in patients with PDAC. PMID: 27802195
    10. High expression of BIRC7 is associated with drug resistance in Renal cell carcinoma. PMID: 27677286
    11. Data show that cylindromatosis (CYLD) overexpression and livin knockdown might improve gemcitabine chemosensitivity by decreasing autophagy and increasing apoptosis in bladder cancer (BCa) cells. PMID: 27448305
    12. The apoptosisinducing effects of livin and surivin knockdown were investigated using a Hoechst staining kit. PMID: 26708654
    13. Expression of livin, survivin and caspase-3 are closely related to the occurrence and development of prostatic cancer. PMID: 26823716
    14. Our results suggested the important role of Livin and its partner molecule in the process of VSV treatment PMID: 26412467
    15. Data showed that Livin knock-down suppressed cell proliferation and inhibited cell invasion, accompanied by downregulation of VEGF and MMP-2/-9. Its silencing resulted in the prevention of xenograft tumor formation. PMID: 26094984
    16. These findings suggest that livin may be used as a novel target for tumor gene therapy. PMID: 25695324
    17. Upregulation of Livin expression and downregulation of caspase activity are observed under cycling and chronic hypoxia in glioblastoma cells and xenografts. PMID: 25370472
    18. Livin expression was higher in condyloma acuminatum than in normal cells and was correlated with survivin and Ki-67. PMID: 26122233
    19. Livin gene has a high expression in osteosarcoma and inhibits apoptosis in tumor tissue. PMID: 25374170
    20. livin is associated with invasive and oncogenic phenotypes such as tumor cell invasion, tumor cell migration, tumor cell proliferation, and resistance to apoptosis in human oral squamous cell carcinoma cells. PMID: 25242075
    21. These data suggest that livin overexpression plays an important role in tumor invasiveness by mediating resistance to apoptosis. PMID: 25339450
    22. effectively silence Livin gene expression in LoVo colon cancer cells, inhibit cell proliferation and colony formation, induce apoptosis, and enhance sensitivity to cisplatin PMID: 24938471
    23. In diagnostically difficult cases of diffuse large B-cell lymphoma and Hodgkin lymphoma, focus on livin as marker may provide useful corroborative information. PMID: 24767895
    24. Low livin expression is associated with childhood acute lymphoblastic leukemia. PMID: 24696218
    25. Co-silencing of Livin and Survivin can effectively inhibit the cell proliferation and apoptosis of lung cancer cells. PMID: 25261663
    26. Livin expression was not associated with survival in pancreas ductal adenocarcinoma. PMID: 25090821
    27. our findings indicate that the expression of Livin is increased in human GC and correlates with tumor differentiation and lymph node metastases PMID: 24220265
    28. The expression of Livin was was independently related to survival in rectal cancer patients PMID: 24295240
    29. Livin expression was positively correlated with the proliferation marker Ki-67, but was negatively correlated with caspase-3 expression in human ampullary carcinoma patients. PMID: 23343959
    30. Data suggest that Livin has a role in thrombopoiesis by regulating the apoptotic and antiapoptotic balance in MK endoreplication and platelet production. PMID: 24287698
    31. High livin expression is associated with lymph node micrometastasis in non-small cell lung cancer. PMID: 23404657
    32. no significant correlation was found between Livin expression and various clinicopathological parameters including survival. PMID: 24008725
    33. Livin is associated with tumor progression by increasing tumor cell motility and inhibiting apoptosis in colorectal cancer PMID: 24023847
    34. our data suggest that Livin is involved in tumorigenesis of human osteosarcoma and may serve as a promising therapeutic target for osteosarcoma. PMID: 23632777
    35. Livin interaction with caspase-3 and Livin role in the regulation of cell death PMID: 23563149
    36. BRG1 regulates ML-IAP expression by cooperating with MITF to promote transcriptionally permissive chromatin structure on the ML-IAP promoter. PMID: 23480510
    37. High BIRC7 expression is associated with lymph node metastasis in squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder. PMID: 23906305
    38. Livin expression promotes breast cancer metastasis through the activation of AKT signaling and induction of EMT in breast cancer cells both in vitro and in vivo. PMID: 23524337
    39. Livin may inhibit apoptosis in cervical squamous cell carcinoma by downregulating caspase-3, thereby promoting disease progression. PMID: 23781587
    40. Genistein can suppress Livin gene expression, induce melanoma cell apoptosis, hinder the cell cycle, and restrain cell proliferation. PMID: 22931613
    41. Survivin and livin mRNA levels in patients with lung cancer were significantly higher than in those with benign lung disease. PMID: 22930255
    42. The increased expression of CD44v6 and Livin in gastric cancer tissue may be closely related with development and progression of gastric cancer. PMID: 22932199
    43. Overexpression of Livin led to cisplatin resistance in colon cancer. PMID: 23188704
    44. study demonstrated the expression of inhibitor of apoptosis proteins, survivin and Livin and the pro-apoptotic protein TSP-1 in endemic Burkitt lymphoma (BL); no significant difference was found between BL and reactive lymphoid hyperplasia PMID: 23030305
    45. Livin expression may be regulated by miR-198 in human prostate cancer cell lines. PMID: 23069480
    46. our data reveal a new, Livin-dependent, apoptotic role for TEAD1 in mammals and provide mechanistic insight downstream of TEAD1 deregulation in cancers. PMID: 23029054
    47. study concludes PTEN and Livin are important in renal clear cell carcinoma development PMID: 22938441
    48. data suggested that livin plays an important role in inhibiting the apoptosis of ovarian cancer cells PMID: 22766624
    49. Bortezomib and arsenic trioxide can induce apoptosis by inhibiting the expression of livin mRNA in Jurkat cells. PMID: 21867610
    50. Livin and survivin may be involved in the pathogenesis and progression of adult acute lymphoblastic leukemia. PMID: 21867615

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Golgi apparatus. Note=Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.
  • 蛋白家族：
    IAP family
  • 组织特异性：
    Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and
  • 数据库链接：

    HGNC: 13702

    OMIM: 605737

    KEGG: hsa:79444

    STRING: 9606.ENSP00000217169

    UniGene: Hs.256126