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BLOC1S6 Antibody

  • 货号：
    CSB-PA890745DSR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: BLOC1S6 antibody at 3.33µg/ml
      Lane 1: A431 whole cell lysate
      Lane 2: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 20, 9 kDa
      Observed band size: 20 kDa
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA890745DSR2HU at dilution of 1:100
    • Immunoprecipitating BLOC1S6 in HEK293 whole cell lysate
      Lane 1: Rabbit control IgG instead of (1µg) instead of CSB-PA890745DSR2HU in HEK293 whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
      Lane 2: CSB-PA890745DSR2HU (4µg) + HEK293 whole cell lysate (500µg)
      Lane 3: HEK293 whole cell lysate (20µg)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) BLOC1S6 Polyclonal antibody
  • Uniprot No.：
    Q9UL45
  • 基因名：
    BLOC1S6
  • 别名：
    Bloc1s6 antibody; iogenesis of lysosome-related organelles complex 1 subunit 6 antibody; PA antibody; Pallid (mouse) homolog antibody; PALLID antibody; Pallid protein antibody; Pallid protein homolog antibody; Pallidin antibody; Pallidin homolog (mouse) antibody; PLDN antibody; PLDN_HUMAN antibody; Syntaxin 13 binding protein antibody; Syntaxin 13-interacting protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 6 protein (1-170AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IP
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IP 1:200-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.
  • 基因功能参考文献：
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that BLOC1S6 (PLDN) is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    2. PLDN is a direct target of RUNX1 and its dysregulation is a mechanism for platelet dense granule deficiency associated with RUNX1 haplodeficiency PMID: 28075530
    3. Mecp2 regulates the expression of components belonging to the dysbindin interactome PMID: 23750231
    4. role in biogenesis of lysosome-related organelles PMID: 12191018
    5. no defects in the known components of pallidin-muted complex (BLOC-1)have been identified in 142 patients with HPS, suggesting that BLOC-1 function may be critical in humans. PMID: 12576321

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  • 相关疾病：
    Hermansky-Pudlak syndrome 9 (HPS9)
  • 亚细胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    BLOC1S6 family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 8549

    OMIM: 604310

    KEGG: hsa:26258

    STRING: 9606.ENSP00000220531

    UniGene: Hs.7037