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BMPER Antibody

  • 货号：
    CSB-PA839829LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA839829LA01HU diluted at 1:200 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) BMPER Polyclonal antibody
  • Uniprot No.：
    Q8N8U9
  • 基因名：
    BMPER
  • 别名：
    BMP binding endothelial regulator antibody; BMP binding endothelial regulator precursor protein antibody; BMP-binding endothelial regulator protein antibody; BMPER antibody; BMPER_HUMAN antibody; Bone morphogenetic protein binding endothelial cell precursor derived regulator antibody; Bone morphogenetic protein-binding endothelial cell precursor-derived regulator antibody; CRIM3 antibody; Crossveinless 2 antibody; CV 2 antibody; CV2 antibody; hCV2 antibody; Protein crossveinless 2 antibody; Protein crossveinless-2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human BMP-binding endothelial regulator protein (271-418AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，BMPER Antibody (CSB-PA839829LA01HU)，的标记方式是Non-conjugated。对于BMPER Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA839829LB01HU BMPER Antibody, HRP conjugated ELISA
    FITC CSB-PA839829LC01HU BMPER Antibody, FITC conjugated
    Biotin CSB-PA839829LD01HU BMPER Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.
  • 基因功能参考文献：
    1. Overexpression of BMPER remarkably enhanced BMP-2-induced osteogenic differentiation, while suppression of BMPER effectively inhibited this process both in vitro and in vivo. PMID: 29518774
    2. that BMPER-modulated BMP pathway activity regulates VE-cadherin expression and vascular barrier function PMID: 27995357
    3. BMPER variants associated with a novel, attenuated subtype of diaphanospondylodysostosis. PMID: 26467725
    4. BMPER-dependent pathway involved in high glucose induced alkaline phosphatase expression in vascular smooth muscle cells. PMID: 26264461
    5. The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis. PMID: 25503991
    6. BMPER is a novel regulator of the osteoblast-like differentiation of HCASMCs. PMID: 22778264
    7. Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis. PMID: 22772758
    8. The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER. PMID: 22020334
    9. Mutual regulation by BMP-9 and CV2 is essential in regulating the development of the vascular endothelium. PMID: 22474252
    10. Diaphonospondylodysostosis is caused by loss of BMPER function. PMID: 21990102
    11. BMPER-mediated signaling plays an essential role in vertebral segmentation early in human development, while defects in BMPER produce Diaphanospondylodysostosis. PMID: 20869035
    12. BMPER is a novel BMP-binding protein that is expressed by endothelial cell precursors, has BMP-antagonizing activity, and may play a role in endothelial cell differentiation by modulating local BMP activity PMID: 12897139
    13. Crossveinless-2 is an inhibitor of BMP function PMID: 14766204
    14. BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. PMID: 18787191

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  • 相关疾病：
    Diaphanospondylodysostosis (DSD)
  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Highly expressed in lung, and brain and also in primary chondrocytes.
  • 数据库链接：

    HGNC: 24154

    OMIM: 608022

    KEGG: hsa:168667

    STRING: 9606.ENSP00000297161

    UniGene: Hs.660998