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BPIFB1 Antibody

  • 货号：
    CSB-PA072508
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA072508(BPIFB1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA072508(BPIFB1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q8TDL5
  • 基因名：
    BPIFB1
  • 别名：
    BPIFB1 antibody; C20orf114 antibody; LPLUNC1 antibody; UNQ706/PRO1357BPI fold-containing family B member 1 antibody; Long palate antibody; lung and nasal epithelium carcinoma-associated protein 1 antibody; von Ebner minor salivary gland protein antibody; VEMSGP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human BPIFB1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS.
  • 基因功能参考文献：
    1. BPIFA1 and BPIFB1 expressions are correlated with goblet cell metaplasia and inversely correlated with lung function parameters of airway obstruction (FEV1 and FEV1/FVC) in COPD patients. PMID: 29296079
    2. The G allele of rs1078761 may be detrimental to lung function in cystic fibrosis owing to decreased levels of BPIFA1 and BPIFB1. PMID: 25574903
    3. higher sputum concentrations of BPIFB1 were associated with changes of lung function over time, especially in current smokers with chronic obstructive pulmonary disease. BPIFB1 may be involved in the pathogenesis of smoking-related lung diseases. PMID: 25979078
    4. Autoimmunity targeting the lung-specific antigen BPIFB1 may contribute to the pathogenesis of interstitial lung disease. PMID: 24107778
    5. Results suggest that LPLUNC1 can inhibit inflammation and nasopharyngeal carcinoma (NPC) growth by downregulating the Stat3 pathway. PMID: 23708661
    6. LPLUNC1 delays nasopharyngeal carcinoma cell growth by inhibiting the MAP Kinase and cyclin D1/E2F pathways. PMID: 23650533
    7. It was shown that there was a significant increase in LPLUNC1 in the airways of patients with cystic fibrosis, but it is unclear if this increase influences the development of lung disease. PMID: 22767025
    8. These results demonstrate that LPLUNC1 is expressed in Paneth cells and likely plays a role in modulating host inflammatory responses to Vibrio cholerae infection. PMID: 21900486
    9. LPLUNC1 is an abundant, secreted product of goblet cells and minor mucosal glands of the respiratory tract and oral cavity and suggest that the protein functions in the complex milieu that protects the mucosal surfaces in these locations. PMID: 20237794
    10. LPLUNC1 is found to be down-expressed in 33 of 48 nasopharyngeal carcinoma biopsies. PMID: 12874788
    11. We found a significant association of cholera with a marker in the promoter region of LPLUNC1 (rs11906665), a member of a family of evolutionarily conserved innate immunity proteins PMID: 19212328

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    BPI/LBP/Plunc superfamily, Plunc family
  • 组织特异性：
    Detected in duodenum mucosal crypts of cholera patients, near Paneth cells (at protein level). Detected in trachea, nasal septal epithelium and lung.
  • 数据库链接：

    HGNC: 16108

    KEGG: hsa:92747

    STRING: 9606.ENSP00000253354

    UniGene: Hs.65551