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  4. BRF2 Antibody

BRF2 Antibody

  • 中文名称：
    BRF2兔多克隆抗体
  • 货号：
    CSB-PA002810GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9HAW0
  • 基因名：
    BRF2
  • 别名：
    B-related factor 2 antibody; BRF-2 antibody; BRF2 antibody; BRF2_HUMAN antibody; BRFU antibody; FLJ11052 antibody; hBRFU antibody; hTFIIIB50 antibody; RNA polymerase III transcription initiation factor BRF2 antibody; TFIIIB50 antibody; Transcription factor IIB- related factor TFIIIB50 antibody; Transcription factor IIIB 50 kDa subunit antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human BRF2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress.
  • 基因功能参考文献：
    1. Results show that the mRNA and protein expression levels of BRF2 were markedly higher in non-small cell lung cancer (NSCLC) cells and highly related to differentiation degree, lymph node metastasis, clinical stage, and vascular invasion. miR-373 was identified to directly target BRF2, resulting in the enhanced migration and invasion of NSCLC A549 cells and indicating that BRF2 affects the metastasis of NSCLC. PMID: 29025258
    2. REVIEW: highlights the interplay of Brf2 with the Nrf2/Keap1 pathway, as well as the role of Brf2 in cancer and other possible regulations PMID: 28854119
    3. Data indicate the crystal structure of a Brf2-TBP-Bdp1 complex bound to a DNA promoter. PMID: 28743884
    4. Study solved crystal structures of a human Brf2-TATA-binding complex bound to natural promoters, obtaining a detailed view of the molecular interactions occurring at Brf2-dependent Pol III promoters and highlighting the general structural and functional conservation of human Pol II and Pol III pre-initiation complexes. PMID: 26638071
    5. hnRNP F is a co-factor in a subset of tristetraprolin/BRF1/BRF2-mediated mRNA decay. PMID: 24978456
    6. These results suggested that BRF2 overexpression in tumor tissues is significantly associated with the poor prognosis of NSCLC patients through promoting epithelial-mesenchymal transition (EMT) program. PMID: 24738062
    7. BRF2 may have a role in poor prognosis and anti-angiogenic therapy for early-stage non-small cell lung cancer PMID: 24523874
    8. High expression of BRF2 is closely associated with tumor progression, angiogenesis, and poor survival in esophageal squamous cell cancer. PMID: 23550276
    9. BRF2 can serve as a marker for lung squamous cell carcinoma and may provide a novel target for therapy. PMID: 20668658
    10. C-terminal domain of Brf2 is required for efficient association of the protein with U6 promoter-bound TBP and SNAP(c), a type 3 promoter-specific transcription factor, and for efficient recruitment of Bdp1 PMID: 16227591
    11. deregulation of Brf1 and Brf2 expression could be a key mechanism responsible for the observed deregulation of RNA pol III transcription in cancer cells PMID: 18700021

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TFIIB family
  • 数据库链接：

    HGNC: 17298

    OMIM: 607013

    KEGG: hsa:55290

    STRING: 9606.ENSP00000220659

    UniGene: Hs.709301