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BST1 Antibody

  • 货号：
    CSB-PA005863
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of PC12 cells using BST-1 Polyclonal Antibody.
  • 其他：

产品详情

  • Uniprot No.：
    Q10588
  • 基因名：
    BST1
  • 别名：
    ADP ribosyl cyclase 2 antibody; ADP-ribosyl cyclase 2 antibody; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 antibody; Bone marrow stromal antigen 1 antibody; Bone marrow stromal cell antigen 1 antibody; BST 1 antibody; BST-1 antibody; BST1 antibody; BST1_HUMAN antibody; cADPr hydrolase 2 antibody; CD157 antibody; CD157 antigen antibody; Cyclic ADP ribose hydrolase 2 antibody; Cyclic ADP-ribose hydrolase 2 antibody; NAD(+) nucleosidase antibody; OTTHUMP00000217617 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human BST-1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.
  • 基因功能参考文献：
    1. SNPs rs28532698 and rs4301112 in CD157 are not significantly associated with childhood autism spectrum disorder or the severity of the disease in a Chinese Han population. PMID: 29216786
    2. the rs4698412 variant of BST-1 may increase the Parkinson disease susceptibility. [META-ANALYSIS] PMID: 25986899
    3. Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells. PMID: 24413464
    4. A pre-steady state and steady state kinetic analysis of the N-ribosyl hydrolase activity of hCD157. PMID: 25250980
    5. Studies indicate that vertebrate ADP-ribosyl cyclases (ARCs) Bst1 and CD38 with common gene structure of invertebrate ARC, suggesting the origin to the ancestor of bilaterian animals. PMID: 24896331
    6. Autism and with features of regression-previously acquired speech lost in the second year of life. The younger sister, who also had asthma, inherited a maternal deletion of 4p15.32 that results in a BST1-CD38 fusion transcript. PMID: 24634087
    7. BST1 rs11724635 polymorphism can interact with well water drinking to increase the risk of Parkinson's disease in a Taiwanese population. PMID: 24342025
    8. These findings indicate a central role of CD157 in cell-extracellular matrix interactions and make CD157 an attractive therapeutic target in inflammation and cancer. PMID: 24753259
    9. These results demonstrate for the first time that CD157 plays a role as a neuro-regulator and suggest a potential role in pre-motor symptoms in Parkinson's disease. PMID: 24795584
    10. A ligand-receptor complex SCRG1/BST1 axis facilitate mesenchymal stem cells migration, preserve OCT4 and CD271 expression, self-renewal and osteogenic differentiation. PMID: 24413464
    11. The results of this study indicated that the SNCA and BST1 SNPs generally increase the risk of developing PD and that SNCA rs11931074 in particular is associated with a higher risk of parkinson disease with family history. PMID: 23853107
    12. The results of this study showed that no causative mutation in the BST1 gene in patients with Parkinson's disease. PMID: 23827523
    13. This study confirmed the associations of BST1 with parkinson disease susceptibility and fail to show significant associations of alzheimer disease genome-wide association study (GWAS) top hits with PD susceptibility in a Korean population. PMID: 23820587
    14. BST1 SNPs rs11931532, rs12645693, & rs11724635 did not correlate with sporadic PD. The relationship of rs11724635 & sporadic PD had borderline significance. Smoking or caffeine intake did not correlate with SNP rs11724635 affecting sporadic PD. PMID: 23026536
    15. Findings implicate CD157 in the progression of EOC to metastatic disease and suggest that CD157 may represent a valuable therapeutic target. PMID: 22916288
    16. The SNPs investigated in the BST1, PARK15 and PARK9 genes associated with PD susceptibility are not associated with PD in the northern Han Chinese population. PMID: 22490479
    17. Direct replication of single nucleotide polymorphisms (SNPs) within SNCA and BST1 confirmed these two genes to be associated with the Parkinson's Disease in the Netherlands. PMID: 21248740
    18. The CD157-integrin partnership provides optimal adhesion and transmigration of human monocytes. PMID: 21478153
    19. found converging evidence of association with Parkinson's disease on 12q24 (rs4964469, combined P = 2.4 x 10(-7)) and confirmed the association on 4p15/BST1 (rs4698412, combined P = 1.8 x 10(-6)), previously reported in Japanese data PMID: 21084426
    20. PARK16, PARK8, and PARK1 loci but not BST1 are found to be associated with Parkinson's disease. PMID: 20697102
    21. CD157 plays a pivotal role in the control of ovarian cancer cell migration and peritoneal invasion, and it may be clinically useful as a prognostic tool and therapeutic target. PMID: 20639476
    22. crystal structures of the extracellular region of human BST-1 at atomic resolution in the free form and in complexes with five substrate analogues: nicotinamide, NMN, ATPgammaS, ethenoNADP, and ethenoNAD PMID: 11866528
    23. CD157 molecule displays two distinct domains in its extracellular component. The first is implicated in the enzymic activities of the molecule and the second features adhesion/signalling properties [review] PMID: 12415565
    24. Deficient in paroxysmal nocturnal hemoglobinemia; crucial to regulation of innate immunity during inflammation. PMID: 15328157
    25. The results confirm that CD157 physically interacts with CD11b/CD18 complex in human neutrophils PMID: 18211745
    26. Results show that CD38 and CD157 are expressed constitutively by corneal cells: CD38 appears as a 45-kDa monomer, while CD157 is a 42- to 45-kDa doublet. PMID: 19052657

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    ADP-ribosyl cyclase family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 1118

    OMIM: 600387

    KEGG: hsa:683

    STRING: 9606.ENSP00000265016

    UniGene: Hs.720344