Birc5 Antibody

1. The present results indicated that PPARgamma may serve a protective role on bEnd.3 cells and that BIRC5 may be a downstream target of PPARgamma regulation during cerebral ischemia. PMID: 29039513
2. While induced by exposure to reactive oxygen species generating stresses, the ultimate expression of changes in radiation response is dependent upon the bi-functionality of the tumor associated protein survivin and its intracellular translocation. PMID: 27427516
3. HDL-associated sphingosine 1-phosphate inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. PMID: 28038379
4. Survivin also attenuates DNA damage related to PARP activation and inhibits TNFalpha-induced lipolysis, suggesting that Survivin may facilitate adipocyte maintenance in response to inflammatory stimuli. PMID: 28055005
5. The study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via survivin. PMID: 27678504
6. this study shows that that sorafenib promotes the survival of bone marrow cells by up-regulating survivin PMID: 27440860
7. Survivin was regulated by TGF-beta and was found to be highly expressed during mucosal healing following intestinal inflammation PMID: 27715398
8. SurvivinT34A combined with arsenic trioxide induces a loss of mitochondria membrane potential PMID: 27748945
9. Survivin is a key regulator of gut tissue integrity by regulating epithelial homeostasis in the stem cell niche. PMID: 26832409
10. TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin and inhibit Wnt in CPCs to mediate cardioprotection and improve cardiac function. PMID: 26418219
11. Survivin is a key gene for regulating squamous cell carcinoma (SCC) cancer stem cell formation and cancer SCC development. PMID: 26771605
12. In colorectal cancer mice with downregulated expression of survivin, there were higher numbers of apoptotic cells and decreased expression levels of bcl2 and ki67. PMID: 26722528
13. survivin is essential for B cell division but does not affect survival of naive B cells. Survival of proliferating B cells may be impacted indirectly by survivin deficiency because of increased genotoxic stress caused by failed chromosomal segregation. PMID: 26810226
14. Survivin directly participates in PRL-mediated beta cell proliferation via Akt, STAT5-PIM and ERK signalling pathways during pregnancy PMID: 26099856
15. Studied competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model. PMID: 25678789
16. Results suggest a role for survivin in regulating adult neural precursor activity and inhibiting apoptosis or programmed cell death in the dentate gyrus following brain injury PMID: 25987205
17. NR4A1 protects pancreatic beta-cells against endoplasmic reticulum stress-mediated apoptosis by up-regulating Survivin expression and down-regulating CHOP expression. PMID: 26157144
18. Studies indicate the importance of survivin in Sonic hedgehog (SHH)-driven medulloblastoma (MB). PMID: 25241898
19. the Skp1.Cul1.F-box protein complex subunit Fbxl7 modulates mitochondrial function by controlling the cellular abundance of survivin PMID: 25778398
20. Both HIF1-alpha and survivin are involved in the retinal neovascularization in oxygen-induced retinopathy. PMID: 25400763
21. survivin-mediated radio-adaptive response is dependent upon the ability of cells to activate NFkappaB PMID: 25763931
22. These findings provide evidence for the existance of a posititve feedback loop connecting survivin expression in tumor cells to PI3K/Akt enhanced beta-catenin-Tcf/Lef-dependent transcription followed by secretion of VEGF and angiogenesis. PMID: 25204429
23. Survivin has an important role in regulating folliculogenesis and oogenesis in the adult mouse ovary. PMID: 24675472
24. Survivin partially regulates HSC function by modulating the Evi-1 transcription factor and its downstream targets PMID: 24903482
25. The study shows that the inhibition of survivin is sufficient to reduce joint inflammation and bone damage in preclinical models of arthritis PMID: 25381389
26. Survivin haploinsufficiency in syngeneic grafts was associated with Ischemia/reperfusion tissue injury, which triggered inflammation eventually resulting in graft loss. PMID: 24731002
27. UHRF1 is strongly up-regulated during liver regeneration independently of BIRC5. PMID: 24818710
28. Findings support the importance of adhesion molecules (VE-cadherin and CD31), survivin, and Ajuba in modulating the Hippo pathway, which regulates, in part, proliferation and survival in hemangioendotheliomas. PMID: 25266662
29. Survivin may be an essential mediator of cyto-protection in podocytes injury. PMID: 24747598
30. The survivin cascade in neural progenitor cells plays a role in anti-apoptosis. PMID: 24022164
31. Data suggest that toll-like receptor 3 (TLR3), phosphatidylinositol 3-kinase (PI3K), survivin, Fas ligand (FasL), and CD95 (Fas) genes are involved in the development of cervical cancer. PMID: 25106857
32. A 3M-CUL9-survivin pathway is implicated in maintaining microtubule and genome integrity, normal development, and tumor suppression. PMID: 24793696
33. Data indicate that loss of survivin in conditional Pten deletion mouse model delays prostate tumor progression. PMID: 23936028
34. The present studies aim to examine whether and how cilia function (Pkd1 or Pkd2) and structure (Tg737) play a role in cystic kidney and aneurysm through survivin downregulation. PMID: 24235270
35. Increased expression of survivin correlates with the proliferation of neural stem cells in the DG of the hippocampus soon after traumatic brain injury. PMID: 23900556
36. STAT3 phosphorylation and subsequent upregulation of survivin expression mediated by Notch-2 signaling in renal proximal tubule epithelial cells aid in the functional and structural recovery of the kidney from acute kidney injury. PMID: 23949800
37. sticky siRNAs against survivin and cyclin B1 efficiently blocks growth of established subcutaneaous B16-F10 tumors as well as formation and dissemination of melanoma lung metastases. PMID: 23835136
38. Data suggest survivin is a key mediator of cytoprotection in acute lung injury (as seen in antineoplastic-induced pulmonary fibrosis); survivin appears to act at epithelial/mucosal cell level; survivin action depends partly on apoptosis inhibition. PMID: 23979427
39. Data from Pak1 knockout mice and RNA interference in cells suggest Pak1 has role in regulation of survivin ubiquitination/stability in beta-cells; impaired proliferation of beta-cells induced by loss of PAK1 is restored by overexpression of survivin. PMID: 23514967
40. survivin inhibition/down-regulation with flavopiridol or specific shRNAs increased the apoptotic response of old fibroblasts to various genotoxic agents PMID: 22252435
41. These results suggest that OX40 costimulation crucially engages survivin during antigen-mediated Th2 responses PMID: 23616302
42. Thimerosal induces S phase arrest and finally causes apoptosis via inhibition of PI3K/Akt/survivin signaling. PMID: 23145070
43. vaccination with recombinant Fowlpox expressing survivin improves T-cell responses against aggressive Malignant mesothelioma tumors and may form the basis for promising clinical applications. PMID: 23335100
44. Our data support a function of survivin in hippocampal synaptic plasticity and learning and underline the importance of adult brain neurogenesis for proper operation of the hippocampal tri-synaptic circuit and the physiological functions that depend on it PMID: 23123921
45. This study identified a novel role for survivin in erythroblast enucleation through previously unknown protein partners. PMID: 22491741
46. overexpression of Bmi1 induces repressive epigenetic regulation of the promoter of Survivin, a well-characterized antiapoptotic protein. PMID: 23132836
47. prepared two mutant forms of the PhSurv-PhTERT tandem with two or four Sp1 sites removed from the distal "long" PhSurv promoter PMID: 23056318
48. Survivin prevents apoptosis by binding to caspase-3 in astrocytes infected with the BeAn strain of Theiler's murine encephalomyelitis virus. PMID: 22638909
49. these data suggest a potentially novel role for survivin in functionally promoting astrocytic proliferation after intracerebral hemorrhage PMID: 22862734
50. Survivin is a dual regulator of lens epithelial cell proliferation and lens fiber cell differentiation. PMID: 23213276

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KEGG: mmu:11799

STRING: 10090.ENSMUSP00000079124

UniGene: Mm.8552