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  4. C11orf73 Antibody

C11orf73 Antibody

  • 货号：
    CSB-PA003035GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q53FT3
  • 基因名：
    HIKESHI
  • 别名：
    C11orf73 antibody; Chromosome 11 open reading frame 73 antibody; CK073_HUMAN antibody; FLJ43020 antibody; Hikeshi antibody; HSPC138 antibody; HSPC179 antibody; L7RN6 antibody; Lethal Chr 7 Rinchik 6 antibody; OPI10 antibody; Protein Hikeshi antibody; Uncharacterized protein C11orf73 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human C11orf73
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
  • 基因功能参考文献：
    1. Our results suggest that HIKESHI is a marker of cancer progression and that the combination of HIKESHI inhibition and hyperthermia is a therapeutic tool for refractory gastric cancer PMID: 28731175
    2. Depletion of Hikeshi renders HeLa cells proteotoxic stress-sensitive through the abrogation of the nuclear function of HSP70s required for HSF1 regulation. PMID: 28980748
    3. A novel homozygous variant in HIKESHI was identified in a patient with hypomyelinating leukoencephalopathy with periventricular cysts and vermian atrophy. Modified interactions inside Hikeshi's hydrophobic pockets induce mutant protein instability. PMID: 28000699
    4. Leukoencephalopathy and early death associated with an Ashkenazi-Jewish founder mutation in the Hikeshi gene.P.V54L mutation in Hikeshi is associated with absence of nuclear HSP70 during heat shock stress. PMID: 26545878
    5. The crystal structure of Hikeshi explains how Hikeshi participates in the regulation of nuclear import through the recognition of FG-Nups and which part of Hikeshi affects its binding to Hsp70. PMID: 25760597
    6. identify a nuclear import pathway that operates during heat shock stress and is mediated by an evolutionarily conserved protein, Hikeshi (coded by the C11orf73 gene) binds to FG-Nups and translocates through nuclear pores on its own, showing characteristic features of nuclear transport carriers. PMID: 22541429

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  • 相关疾病：
    Leukodystrophy, hypomyelinating, 13 (HLD13)
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytosol. Nucleus.
  • 蛋白家族：
    OPI10 family
  • 数据库链接：

    HGNC: 26938

    OMIM: 614908

    KEGG: hsa:51501

    STRING: 9606.ENSP00000278483

    UniGene: Hs.283322