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C2orf40 Antibody

  • 货号：
    CSB-PA070024
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9H1Z8
  • 基因名：
    C2orf40
  • 别名：
    AUGN_HUMAN antibody; Augurin antibody; C2orf40 antibody; Esophageal cancer-related gene 4 protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ECRG4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system. ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation.
  • 基因功能参考文献：
    1. we have provided evidence to show that Ecrg4 is constitutively expressed in atria and the conduction systems and is down-regulated in AF. PMID: 28578429
    2. mutations in Pakistani patients with dilated cardiomyopathy rs375563861 (C2orf40), rs143187236 (MYOM3), and rs564181443 (RTKN2) have 3 fold or higher allele frequency in South Asians than in the global populations PMID: 29886034
    3. ECRG4 down-regulates UBE2C expression in esophageal squamous cell carcinoma cells. PMID: 29268240
    4. Results from many studies support the discovery that ECRG4 plays a critical role in the pathogenesis of atrial fibrillation. [review] PMID: 29126922
    5. UBR5 directly binds to the tumor suppressor esophageal cancer-related gene 4, increasing its ubiquitination to reducing the protein stability of ECRG4 to promote colorectal cancer progression. PMID: 28856538
    6. positive and negative regulatory elements controlling ECRG4 expression include a counter regulation between promoter methylation and Sp1 activation. PMID: 28870864
    7. the overexpression of Beclin 1 promoted apoptosis and decreased invasion by upregulating the expression of ECRG4 in A549 lung adenocarcinoma cells. Therefore, the selection of Beclin l as a target for gene therapy represents a more effective method for the treatment of lung cancer. PMID: 27175789
    8. Downregulated ECRG4 is correlated with lymph node metastasis in nasopharyngeal carcinoma PMID: 27119734
    9. The overexpression of ECRG4 inhibited tumorigenesis. PMID: 26762416
    10. ECRG4 may be a tumor suppressor in renal cancer and serve as a prognostic marker PMID: 26276361
    11. low expression or no expression of ECRG4 in esophageal cancer tissues was closely related to the degree of tumor invasion level, TNM staging, lymph node metastasis and recurrence and survival after surgery. PMID: 26823803
    12. loss of ECRG4 protein expression may be involved in tumor progression and may serve as a prognostic biomarker for breast cancer. PMID: 26631111
    13. Overexpression of ECRG4 inhibited laryngeal cancer cell proliferation and induced cancer cell apoptosis. PMID: 26165988
    14. Our data suggest that methylation-mediated suppression of the ECRG4 gene occurs frequently in nasopharyngeal carcinoma PMID: 25707757
    15. Results identify Ecrg4 as a paracrine factor that activates microglia and is chemotactic for monocytes, with potential as an antitumor therapeutic. PMID: 25378632
    16. ECRG4 is present on the surface of human monocytes and granulocytes and its interaction with the innate immunity receptor complex supports a role for cell surface activation of ECRG4 during inflammation PMID: 25511108
    17. The expression of ECRG4 is frequently upregulated in a papillary thyroid carcinoma through the demethylation mechanism of CpG islands in the gene promoter region, and the ECRG4 has a tumor-promoting function through inducing the cell cycle transition PMID: 25326809
    18. ECRG4 is a candidate tumor suppressor gene that might be involved in the proliferation of esophageal squamous cell carcinoma PMID: 23957914
    19. results suggest that C2ORF40 acts as a tumor suppressor gene in breast cancer pathogenesis and progression and is a candidate prognostic marker for this disease PMID: 23770814
    20. overexpression of ECRG4 enhanced the chemosensitivity of gastric cancer SGC-7901 cells to 5-FU through induction of apoptosis. PMID: 23553029
    21. Aberrant DNA methylation of ECRG4 gene is associated with colorectal cancer. PMID: 22901147
    22. Aberrant ECRG4 promoter methylation may be used to monitor early gastric cancer and predict pathological staging. PMID: 22626786
    23. DNA methylation of the ECRG4 promoter causes loss of ECRG4 gene expression in the esophageal squamous cell carcinoma cell line EC9706. PMID: 22325214
    24. kDa Ecrg4 localizes to the cell surface of prostate (PC3) or kidney (HEK) epithelial cells after transfection. PMID: 22526622
    25. Tumor necrosis factor-alpha-induced apoptosis was also suppressed in ECRG4-overexpressing Jurkat cells. PMID: 22411956
    26. ECRG4 is a candidate tumor suppressor gene in breast cancer PMID: 22110708
    27. Augurin would play a constitutive inhibitory function in normal CNS while down regulation of Ecrg4 gene expression in injury, like in cancer, dysinhibits proliferation. PMID: 21935431
    28. Data show that ECRG4 interacts directly with ECRG1 to upregulate p21 protein expression, induce cell cycle G1 phase block and inhibit cancer cells proliferation in ESCC. PMID: 21288367
    29. Loss of ECRG4 is associated with glioma. PMID: 20598162
    30. ECRG4 is silenced via promoter hypermethylation in different types of human cancer cells. PMID: 20017917
    31. Inactivation of ECRG 4 gene by hypermethylation is a frequent molecular event in esophageal squamous cell carcinoma and may be involved in the carcinogenesis of this cancer. PMID: 12800218
    32. Significantly lower expression of esophageal cancer-related gene 4 is associated with esophageal squamous cell carcinoma PMID: 17786363
    33. The restoration of ECRG4 expression in ESCC cells inhibited cell proliferation, colony formation, cell cycle progression and tumor growth in vivo. ECRG4 is a novel candidate tumor suppressor gene in ESCC. PMID: 19521989

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  • 亚细胞定位：
    Secreted. Cytoplasm. Apical cell membrane.
  • 蛋白家族：
    Augurin family
  • 组织特异性：
    Expressed in the brain, with expression in the epithelial cell layer of the choroid plexus (at protein level).
  • 数据库链接：

    HGNC: 24642

    OMIM: 611752

    KEGG: hsa:84417

    UniGene: Hs.43125