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C9 Antibody

  • 货号：
    CSB-PA001095
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COLO205 cells using C9 Polyclonal Antibody
    • Western Blot analysis of NIH-3T3 cells using C9 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P02748
  • 基因名：
  • 别名：
    C9; Complement component C9
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human C9.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
  • 基因功能参考文献：
    1. The data supports the assumption that C9 gene expression may stimulate the expression of inflammatory (NLRP3) and angiogenic growth factors (VEGF) in retinal pigment epithelial cells. PMID: 30090015
    2. Serum-expressed apolipoprotein B-100 protein, C9 Complement, and gelsolin can be used for differential diagnosis of Barrertts esophagus and adenocarcinoma of esophagus. PMID: 26404905
    3. Data indicate that complement C9 binds to the ATPase domain of mortalin. PMID: 24719326
    4. Liver biopsy specimens from chronically hepatitis C virus-infected patients exhibited a lower level of C9 mRNA expression than liver biopsy specimens from unrelated disease or healthy control human liver RNA. PMID: 23487461
    5. the haploinsufficiency of C9, a terminal complement complex component, engenders reduced intraocular secretion of VEGF and decreased risk for CNV development. PMID: 22190594
    6. C9 and fucosylated form could serve as a useful marker for SQLC. PMID: 21840429
    7. It was concluded that variations in the complement component 9 gene are unlikely to influence clearance of chronic hepatitis B virus infection and hepatocellular carcinoma occurrence. PMID: 21380615
    8. Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9. PMID: 21507937
    9. These results suggested that the lack of membrane attack complex because of an Arg95Stop mutation of the complement component 9 gene predisposed patients to pathognomonic glomerulonephritis. PMID: 21057849
    10. provided evidence for the recognition of membrane-bound C9 on complement-lysed ghosts by an antibody specific for the helix-turn-helix fold. PMID: 20153530
    11. Data show that mortalin supports cancer cell resistance to complement-dependent cytotoxicity and suggest consideration of mortalin as a novel target for cancer adjuvant immunotherapy. PMID: 19739077
    12. The human complement C9 gene: structural analysis of the 5' gene region and genetic polymorphism studies. PMID: 11881818
    13. C9 binding is dependent on the N-terminal modules (thrombospondin type 1 and low-density lipoprotein receptor class A) of C8 alpha together with the C8 alpha membrane attack complex/perforin domain. PMID: 12463754
    14. Founder effect was demonstrated for the R95X mutation of the C9 gene in Japanese PMID: 12596049
    15. results indicate that the principal binding site for C9 lies within the MACPF domain of C8alpha PMID: 16618117
    16. analysis of the CD59-C9 binding interaction PMID: 16844690

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  • 相关疾病：
    Complement component 9 deficiency (C9D); Macular degeneration, age-related, 15 (ARMD15)
  • 亚细胞定位：
    Secreted. Target cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Complement C6/C7/C8/C9 family
  • 组织特异性：
    Plasma (at protein level).
  • 数据库链接：

    HGNC: 1358

    OMIM: 120940

    KEGG: hsa:735

    STRING: 9606.ENSP00000263408

    UniGene: Hs.654443