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CA3 Antibody

  • 中文名称：
    CA3兔多克隆抗体
  • 货号：
    CSB-PA004371LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: CA3 antibody at 2µg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: HepG2 whole cell lysate
      Lane 3: K562 whole cell lysate
      Lane 4: NIH/3T3 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 30 kDa
      Observed band size: 30 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA004371LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA004371LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CA3 Polyclonal antibody
  • Uniprot No.：
    P07451
  • 基因名：
    CA3
  • 别名：
    CA III antibody; CA-III antibody; Ca3 antibody; CAH3_HUMAN antibody; CAIII antibody; Car3 antibody; Carbonate dehydratase III antibody; Carbonic anhydrase 3 antibody; Carbonic anhydrase III antibody; Carbonic anhydrase III muscle specific antibody; EC 4.2.1.1 antibody; Epididymis secretory sperm binding protein Li 167mP antibody; HEL S 167mP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Carbonic anhydrase 3 protein (2-260AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CA3 Antibody (CSB-PA004371LA01HU)，的标记方式是Non-conjugated。对于CA3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA004371LB01HU CA3 Antibody, HRP conjugated ELISA
    FITC CSB-PA004371LC01HU CA3 Antibody, FITC conjugated
    Biotin CSB-PA004371LD01HU CA3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Reversible hydration of carbon dioxide.
  • 基因功能参考文献：
    1. CAIII and Hsp70 expressions were higher in LPRD patients that in non-LPRD patients, suggesting the possibility as one of biomomarker in LPRD diagnosis. PMID: 26847302
    2. this study detected the formation and colocalization of 6-nitrotryptophan-containing proteins and CAIII in the skin of atopic dermatitis patients, not only in the lesional part but also in the nonlesional part, through histochemical analyses PMID: 24838180
    3. Report that anti-CAIII antibodies may be useful for diagnosing microscopic polyangiitis. PMID: 23981757
    4. The carbonic anhydrase CA3 isoform displayed an increased abundance during muscle aging, which was independently verified by immunoblotting of differently aged human skeletal muscle samples. PMID: 22797148
    5. The generation of CA III and IV autoantibodies, antioxidant enzymes, and cytokines might influence each other. PMID: 23049597
    6. Crystallization and preliminary X-ray analysis of human carbonic anhydrase III PMID: 11976500
    7. Data show that inserting histidine residues into the active site cavity of carbonic anhydrase II or III results in rates of proton transfer to the zinc-bound hydroxide that are antagonistic or suppressive with respect to the corresponding single mutants. PMID: 12171926
    8. Proton transfer within the active-site cavity of carbonic anhydrase III PMID: 12484342
    9. myoglobin/carbonic anhydrase III ratio in the blood proved to be a more specific indicator for myocardial damage than myoglobin alone after myocardial infarction. PMID: 12745799
    10. CAIII expression is upregulated in kidney cortex samples from the end-stage kidney of a patient with Dent's disease owing to the G506E mutation of CLCN5 PMID: 18322545
    11. CAIII promotes transformation and invasion capability in hepatoma cells through FAK signaling pathway. PMID: 18444244
    12. The level of CAIII is specifically insufficient in the skeletal muscle of myasthenia gravis patients. PMID: 19301202

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Alpha-carbonic anhydrase family
  • 组织特异性：
    Muscle specific.
  • 数据库链接：

    HGNC: 1374

    OMIM: 114750

    KEGG: hsa:761

    STRING: 9606.ENSP00000285381

    UniGene: Hs.82129