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CA5A Antibody

  • 货号：
    CSB-PA001099
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of K562 cells using CA VA Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P35218
  • 基因名：
    CA5A
  • 别名：
    CA5A antibody; CA5Carbonic anhydrase 5A antibody; mitochondrial antibody; EC 4.2.1.1 antibody; Carbonate dehydratase VA antibody; Carbonic anhydrase VA antibody; CA-VA antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CA VA.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Reversible hydration of carbon dioxide. Low activity.
  • 基因功能参考文献：
    1. In 10 of 96 patients, mutations in CA5A were identified on both alleles but none in CA5B. Exhibiting decreased enzyme activity or thermal stability, all CAVA mutations were proven to cause disease, whereas the three variants showed no relevant effect PMID: 26913920
    2. CA5A alterations cause hyperammonemia in early childhood that result in mitochondrial carbonic anhydrase VA deficiency PMID: 24530203
    3. activators enhanced kcat, with no effect on KM, favoring the RDS in the catalytic cycle; the activation pattern of the two mitochondrial isoforms is very different from each other and as compared to those of the cytosolic isoforms hCA I and II. PMID: 17174092
  • 相关疾病：
    Hyperammonemia due to carbonic anhydrase VA deficiency (CA5AD)
  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Alpha-carbonic anhydrase family
  • 数据库链接：

    HGNC: 1377

    OMIM: 114761

    KEGG: hsa:763

    STRING: 9606.ENSP00000309649

    UniGene: Hs.177446