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CA8 Antibody

  • 货号：
    CSB-PA060114
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P35219
  • 基因名：
    CA8
  • 别名：
    CA VIII antibody; CA-VIII antibody; Ca8 antibody; CAH8_HUMAN antibody; CALS antibody; Carbonic anhydrase related protein antibody; Carbonic anhydrase VIII antibody; Carbonic anhydrase-related protein antibody; CARP antibody; MGC120502 antibody; MGC99509 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CA VIII.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Does not have a carbonic anhydrase catalytic activity.
  • 基因功能参考文献：
    1. we observed increased expression of CA8 in more aggressive types of human osteosarcoma (OS) cells and found that CA8 expression is correlated with disease stages, such that more intense expression occurs in the disease late stage PMID: 26711783
    2. CA8 overexpression desensitizes neuronal cells to STS induced apoptotic stress and increases cell migration and invasion ability in neuronal cells. PMID: 24794067
    3. Overexpression of CA8 in MERRF cybrids significantly decreases cell death. PMID: 24476000
    4. This report expands the neurological and radiological phenotype associated with CA8 mutations. PMID: 21812104
    5. review article describes the previous data on CARP VIII, including its structure, role in neurodegeneration and cancer; and bioinformatic and expression analyses. PMID: 20819067
    6. Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing PMID: 19360879
    7. Overexpression of Carbonic anhydrase-related protein VIII promotes colon cancer cell growth PMID: 17219437
    8. The results suggest that the variations of CA8 and CA10 loci may be important determinants of osteoporosis in Japanese women. PMID: 19172221
    9. Consanguineous Iraqi family in which affected siblings had mild mental retardation and congenital ataxia characterized by quadrupedal gait. The mutation S100P is associated with proteasome-mediated degradation, and presumably represents a null mutation. PMID: 19461874

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  • 相关疾病：
    Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3)
  • 蛋白家族：
    Alpha-carbonic anhydrase family
  • 数据库链接：

    HGNC: 1382

    OMIM: 114815

    KEGG: hsa:767

    STRING: 9606.ENSP00000314407

    UniGene: Hs.654388