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CACNB4 Antibody

  • 货号：
    CSB-PA004414LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA004414LA01HU at dilution of 1:100
    • Immunofluorescent analysis of PC-3 cells using CSB-PA004414LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CACNB4 Polyclonal antibody
  • Uniprot No.：
    O00305
  • 基因名：
  • 别名：
    CAB4 antibody; CACB4_HUMAN antibody; Cacnb4 antibody; CACNLB4 antibody; Calcium channel voltage dependent beta 4 subunit antibody; Calcium channel voltage dependent subunit beta 4 antibody; Calcium channel voltage-dependent subunit beta 4 antibody; Dihydropyridine sensitive L type calcium channel beta 4 subunit antibody; EA5 antibody; EIG9 antibody; EJM antibody; EJM4 antibody; EJM6 antibody; Voltage-dependent L-type calcium channel subunit beta-4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Voltage-dependent L-type calcium channel subunit beta-4 protein (1-217AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CACNB4 Antibody (CSB-PA004414LA01HU)，的标记方式是Non-conjugated。对于CACNB4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA004414LB01HU CACNB4 Antibody, HRP conjugated ELISA
    FITC CSB-PA004414LC01HU CACNB4 Antibody, FITC conjugated
    Biotin CSB-PA004414LD01HU CACNB4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
  • 基因功能参考文献：
    1. The nuclear targeting properties of the truncated beta(4b(1-481)) subunit in tsA-201 cells, skeletal myotubes, and in hippocampal neurons, were investigated. PMID: 24875574
    2. Genome-wide association studies identify CACNB4 mutation releated to juvenile myoclonic epilepsy. PMID: 23756480
    3. Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy PMID: 22892567
    4. The Ca2+ channel beta4c subunit interacts with heterochromatin protein 1 gama via a PXVXL binding motif. PMID: 21220418
    5. CACNB4 is associated with acute lung injury in mice PMID: 21297076
    6. The novel nucleotide substitution T87C (D29D)in CACNB4 was observed in 2 migrainous vertigo patients and was not present in control DNA samples. PMID: 16866717
    7. No pathogenic mutation were identified in CACNB4. PMID: 18446307
    8. plays a role in neurotransmitter release. PMID: 18712068

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  • 相关疾病：
    Epilepsy, idiopathic generalized 9 (EIG9); Juvenile myoclonic epilepsy 6 (EJM6); Episodic ataxia 5 (EA5)
  • 蛋白家族：
    Calcium channel beta subunit family
  • 组织特异性：
    Expressed predominantly in the cerebellum and kidney.
  • 数据库链接：

    HGNC: 1404

    OMIM: 601949

    KEGG: hsa:785

    STRING: 9606.ENSP00000438949

    UniGene: Hs.120725