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  4. CADM4 Antibody

CADM4 Antibody

  • 货号：
    CSB-PA008004
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of RAW264.7 cells using IGSF4C Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q8NFZ8
  • 基因名：
    CADM4
  • 别名：
    CADM 4 antibody; cadm4 antibody; CADM4_HUMAN antibody; Cell adhesion molecule 4 antibody; IGSF4C antibody; Immunoglobulin superfamily member 4C antibody; Necl 4 antibody; NECL-4 antibody; NECL4 antibody; Nectin like 4 antibody; Nectin like protein 4 antibody; Nectin-like protein 4 antibody; synCAM4 antibody; TSLC1 like 2 antibody; TSLC1 like protein 2 antibody; TSLC1-like protein 2 antibody; TSLL2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human IGSF4C.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.
  • 基因功能参考文献：
    1. There was a significant association between RNase 5 and histological differentiation in colon adenocarcinomas, but no association between RNase 5 and Necl 4 in gastric or colon adenocarcinomas PMID: 28561015
    2. Low CADM4 expression is associated with bone marrow metastasis in neuroblastoma. PMID: 28921546
    3. The results suggest that Necl-4 enhances VEGF-induced activation of PLCgamma-c-Raf-MEK-ERK pathway without affecting the phosphorylation and internalization of VEGFR2. PMID: 28601637
    4. Necl-4 serves as a novel regulator for contact inhibition of cell movement and proliferation cooperatively with the VEGF receptor and PTPN13 PMID: 25893857
    5. results indicate that Necl-4 serves as a tumor suppressor by inhibiting the ErbB2/ErbB3 signaling and hemidesmosome disassembly PMID: 23611113
    6. Loss or decrease of CADM4 expression seems to play an important role in breast cancer invasiveness, and it is associated with poorer biological parameters. PMID: 23559354
    7. Cadm4 regulates the growth of the myelin unit and the organization of the underlying axonal membrane. PMID: 23825401
    8. CADM4, as well as 4.1B is expressed specifically in human proximal tubules. PMID: 21544807
    9. Nec- 4 suppress the growth and tumorigenic ability of colon cancer cells. PMID: 19565570
    10. TSLL2 is expressed at the cell-cell attachment sites in the renal tubules, the transitional epithelia of the bladder, and the glandular epithelia of the prostate, and is a tumor-suppressor candidate in prostate cancer. PMID: 16261159

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Nectin family
  • 组织特异性：
    Expressed in brain, prostate, brain, kidney and some other organs.
  • 数据库链接：

    HGNC: 30825

    OMIM: 609744

    KEGG: hsa:199731

    STRING: 9606.ENSP00000222374

    UniGene: Hs.370984