CALHM1 Antibody
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) CALHM1 Polyclonal antibody
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Uniprot No.:Q8IU99
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基因名:CALHM1
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别名:CALHM1; FAM26C; Calcium homeostasis modulator protein 1; Protein FAM26C
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宿主:Rabbit
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反应种属:Human
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免疫原:Recombinant Human Calcium homeostasis modulator protein 1 protein (202-346AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:Antigen Affinity Purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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产品提供形式:Liquid
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应用范围:ELISA, IHC
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推荐稀释比:
Application Recommended Dilution IHC 1:20-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相关产品
靶点详情
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功能:Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Together with CALHM3, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs). Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to ...显示更多
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基因功能参考文献:
- Meta-analysis suggested that CALHM1 rs2986017 might be associated with increased Alzheimer's disease risk in Caucasian, but not Asian population PMID: 26700797
- In the presence of antibody, P86L-CALHM1 shifts the balance between neurodegeneration and neuronal survival toward the stimulation of pro-cytotoxic pathways, thus potentially contributing to its deleterious effects in Alzheimer's disease. PMID: 26416646
- CALHM1 polymorphism may be potential biomarker in patients with Alzheimer disease. [meta-analysis] PMID: 26944452
- The rare R154H variant interferes with CALHM1 control of cytosolic Ca2+ and Abeta accumulation. PMID: 25386646
- CALHM1 p.P86L variation may not be an AD susceptibility factor in the Han Chinese population. PMID: 24630757
- This study showed that No association between polymorphisms in the calcium homeostasis modulator 1 gene and mesial temporal lobe epilepsy risk in a Chinese population PMID: 24326043
- rare genetic variants in CALHM1 lead to Ca(2+) dysregulation and may contribute to the risk of EOAD through a mechanism independent from the classical Ass cascade. PMID: 24069280
- The study identifies a previously uncharacterized mechanism of control of Ca(2+)-dependent ERK1/2 signaling in neurons, and further establishes CALHM1 as a critical ion channel for neuronal signaling and function. PMID: 23345406
- Our data show that CLHM-1 is a functionally conserved ion channel that plays an important but potentially toxic role in excitable cell function. PMID: 23884934
- Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins. PMID: 23300080
- CALHM1 is a voltage-gated ATP-release channel required for sweet, bitter and umami taste perception PMID: 23467090
- A TGG haplotype defined by the rs4918016-rs2986017-rs2986018 block was associated with sporadic Creutzfeldt-Jakob disease. PMID: 22874670
- An association between the CALHM1 polymorphism and the risk for Alzheimer's disease, was not detected. PMID: 21378601
- Data show a significant association of CALHM1 P86L with elevated CSF Abeta42 and Abeta40 in the normal cohort at risk for Alzheimer's disease. PMID: 21629967
- CALHM1 increases Ca(2+) leak from the ER and, more importantly, reduces the endoplasmic reticulum Ca(2+) uptake by decreasing both the transport capacity and the Ca(2+) affinity of SERCA. PMID: 21574960
- These results indicate that the CALHM1 Pro86Leu polymorphism may modulate age of onset of Alzheimer's disease by interacting with the effect of the epsilon4 allele of apolipoprotein E. PMID: 20847397
- The results of this study provide the first evidence that the SNP rs11191692 in CALHM1 confers highly increased susceptibility to temporal lobe epilepsy. PMID: 21439911
- This study demonistrated that CALHM1 allele (13.5% vs 16.7%) and genotype frequency was not significantly different between Alzheimer's disease (AD) and controls. PMID: 19545933
- the CALHM1 P86L common variant may not influence Alzheimer disease risk in Japanese PMID: 19655363
- Meta-analysis of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20847397
- This study for the first time finds that the GOLPH2 modifies the ApoE[varepsilon]4-associated risk of Alzheimer's disease. PMID: 20592574
- Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20534741
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20574532
- Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20592574
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20634593
- This study failed to show an association between theeight SNPs of the CALHM1 genes and alzheimer disease. PMID: 20164573
- The CALHM1-P86L polymorphism is associated with Alzheimer's disease in the ethnic Chinese Han population. PMID: 20061624
- The present study might help to highlight the CALMH1gene as an excellent candidate for AD genetic susceptibility. PMID: 20164592
- The results of this study did not confirm an association between the CALHM1 variation and AD, thus suggesting a genetic heterogeneity among the various populations. PMID: 20164602
- we found no evidence that CALHM1 P86L is associated with altered CSF levels of the investigated Alzheimer's disease biomarkers A beta 42, tau and phospho-tau PMID: 20005921
- Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20164573
- Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 20164592
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20164602
- Cells carrying the P86L mutation of CALHM1 channel may have mitochondria more vulnerable to Ca2+ overload and to apoptotic stimuli. PMID: 19944073
- Study determined that the CALHM1 P86L polymorphism is associated with Alzheimer's disease, further found that the P86L polymorphism increases amyloid-beta levels by interfering with CALHM1-mediated Ca(2+) permeability. PMID: 18585350
- [Review] Expression of CALHM1 is found in all brain regions and cells of neuronal lineage; it localizes predominantly to the endoplasmic reticulum but also exists at the plasma membrane, where it forms a novel calcium influx route to the cytosol. PMID: 18667147
- Protein may be a genetic determinant of Alzheimer disease, since a polymorphism reduces calcium permeability. PMID: 19038093
- Study assessed the potential association between Alzheimer's Disease risk and the Pro86Leu variant in the CALHM1 gene; no association was observed, either in the individual samples or in the combined analyses of more than 8100 subjects PMID: 19070563
- No association with risk of late-onset Alzheimer disease (p=0.368 for genotypes; p=0.796 for alleles) was observed in the study, however, a potential modest association of minor allele homozygosity (TT) with an earlier age-at-onset was seen. PMID: 19191331
- Study suggests the polymorphism does not contribute significantly to Alzheimer dementia risk in the Belgian population. PMID: 19191332
- CALHM1 polymorphism is not associated with late-onset Alzheimer disease. PMID: 19472444
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20005921
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20061624
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19655363
- Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 19545933
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19472444
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19191331
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19191332
- Observational study of gene-disease association. (HuGE Navigator) PMID: 18585350
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亚细胞定位:Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
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蛋白家族:CALHM family
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组织特异性:Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. Specifically expressed in circumvallate taste bud cells.
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数据库链接:
HGNC: 23494
OMIM: 612234
KEGG: hsa:255022
STRING: 9606.ENSP00000329926
UniGene: Hs.680365