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CALR Antibody

  • 货号：
    CSB-PA004458YA01PI
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Pig CALR Polyclonal antibody
  • Uniprot No.：
    P28491
  • 基因名：
  • 别名：
    CALRCalreticulin antibody; CRP55 antibody; Calregulin antibody; Endoplasmic reticulum resident protein 60 antibody; ERp60 antibody; HACBP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Pig
  • 免疫原：
    Recombinant Pig Calreticulin protein (18-417AA)
  • 免疫原种属：
    Pig
  • 标记方式：
    Non-conjugated

    本页面中的产品，CALR Antibody (CSB-PA004458YA01PI)，的标记方式是Non-conjugated。对于CALR Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA004458YB01PI CALR Antibody, HRP conjugated ELISA
    FITC CSB-PA004458YC01PI CALR Antibody, FITC conjugated
    Biotin CSB-PA004458YD01PI CALR Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy.
  • 基因功能参考文献：
    1. Here the s identify porcine calreticulin expressed by swine intestinal cells as a host-specific receptor for Salmonella Choleraesuis FimH adhesin, suggesting that such an interaction may contribute to Salmonella Choleraesuis host specificity. PMID: 28770174
    2. Calreticulin is confined to subplasmalemmal vesicles partially overlapping with cortical granule contents. Its exocytosis after the oocyte activation seems to participate in the membrane block to polyspermy in pigs. PMID: 24398873
    3. Calreticulin was widely expressed in pig tissues and its transcripts were downregulated during maturation, especially at 44 hr, and were undetectable at the blastocyst stage. PMID: 20222029
  • 亚细胞定位：
    Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen. Cytoplasmic vesicle, secretory vesicle, Cortical granule. Cytolytic granule.
  • 蛋白家族：
    Calreticulin family
  • 组织特异性：
    In blastocyst expressed in all blastomeres (at protein level). In embryos, expressed in spleen, kidney, liver, fat, muscle, ovary, granulosa cells and cumulus cells.
  • 数据库链接：

    KEGG: ssc:100381266

    STRING: 9823.ENSSSCP00000014615

    UniGene: Ssc.48945