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CAMK2N2 Antibody

  • 货号：
    CSB-PA004470NA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of MCF-7 cells with CSB-PA004470NA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CAMK2N2 Polyclonal antibody
  • Uniprot No.：
    Q96S95
  • 基因名：
    CAMK2N2
  • 别名：
    CAMK2N2Calcium/calmodulin-dependent protein kinase II inhibitor 2 antibody; CaM-KII inhibitory protein antibody; CaM-KIIN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Peptide sequence from Human Calcium/calmodulin-dependent protein kinase II inhibitor 2 protein (10-28AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CAMK2N2 Antibody (CSB-PA004470NA01HU)，的标记方式是Non-conjugated。对于CAMK2N2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA004470NB01HU CAMK2N2 Antibody, HRP conjugated ELISA
    FITC CSB-PA004470NC01HU CAMK2N2 Antibody, FITC conjugated
    Biotin CSB-PA004470ND01HU CAMK2N2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.
  • 基因功能参考文献：
    1. Mutant FUS-DeltaNLS increased calcium/calmodulin-dependent protein kinase II inhibitor 2 (CAMK2N2) at both mRNA and protein levels. PMID: 23545117
    2. Murine double minute 2 (MDM2) protein levels were decreased in AD cells relative to control lymphoblasts, suggesting an impairment of FOXO3a degradation. PMID: 23153928
    3. We show that CaMKII N beta expression is differentially regulated by novelty and contextual fear conditioning, providing further insight into molecular basis of fear LTM. PMID: 20487031
    4. hCaMKIINbeta may play an important role in the regulation of tumor cell growth PMID: 19586909
    5. Functional study of the rat homolog PMID: 9724800

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  • 亚细胞定位：
    Nucleus. Cytoplasm, cytosol.
  • 蛋白家族：
    CAMK2N family
  • 组织特异性：
    Expressed in cell lines including hemopoietic cell lines and some tumor cell lines. Highly Expressed in stimulated dendritic cell (DC) and weakly expressed in unstimulated mature and immature DC. Highly expressed in kidney, liver, in cell lines HeLaS3, ly
  • 数据库链接：

    HGNC: 24197

    OMIM: 608721

    KEGG: hsa:94032

    STRING: 9606.ENSP00000296238

    UniGene: Hs.585003