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  4. CAPN7 Antibody

CAPN7 Antibody

  • 货号：
    CSB-PA004500GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y6W3
  • 基因名：
    CAPN7
  • 别名：
    CAPN7 antibody; PALBHCalpain-7 antibody; EC 3.4.22.- antibody; PalB homolog antibody; PalBH antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CAPN7
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Calcium-regulated non-lysosomal thiol-protease.
  • 基因功能参考文献：
    1. The proteolytic activity of CAPN7 is important for the acceleration of EGFR degradation via the endosomal sorting pathway. PMID: 24953135
    2. Data indicate that CAPN 7 promotes endometrial stromal cell (hESC) migration and invasion by increasing the activity of MMP-2 via an increased ratio of MMP-2 to TIMP-2. PMID: 23855590
    3. Mutational analysis of calpain-7 reveals the importance of not only the N-terminal microtubule-interacting and trafficking domains but also the C-terminal C2 domain-like domains for proteolytic activity. PMID: 23497113
    4. The detected enhancement of autolysis of mGFP-fused calpain-7 by coexpression with CHMP1B and observed further activation by additional coexpression of IST1 in HEK293T cells. PMID: 21616915
    5. Results demonstrate that human calpain 7 is proteolytically active, and imply that calpain 7 is activated by ESCRT-III-related protein IST1. PMID: 20849418

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Peptidase C2 family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 1484

    OMIM: 606400

    KEGG: hsa:23473

    STRING: 9606.ENSP00000253693

    UniGene: Hs.595234