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CAPZB Antibody

  • 货号：
    CSB-PA004514ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: CAPZB antibody at 6µg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: A431 whole cell lysate
      Lane 3: Jurkat whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 32, 31 kDa
      Observed band size: 32, 31 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA004514ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CAPZB Polyclonal antibody
  • Uniprot No.：
    P47756
  • 基因名：
  • 别名：
    11 antibody; Cap protein, actin, beta antibody; Cap Z antibody; CAPB antibody; CAPPB antibody; Capping protein (actin filament) muscle Z line beta antibody; Capping protein beta 2 antibody; CAPZ antibody; CapZ beta antibody; Capzb antibody; CAPZB_HUMAN antibody; DKFZp686K0524 antibody; F actin capping protein beta subunit antibody; F-actin-capping protein subunit beta antibody; FLJ12274 antibody; FLJ44693 antibody; MGC104401 antibody; MGC129749 antibody; MGC129750 antibody; wu:fk65f06 antibody; zgc:66149 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human F-actin-capping protein subunit beta protein (1-272AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization.
  • 基因功能参考文献：
    1. CAPZB controls spindle orientation independently of its classical role in the actin cytoskeleton by regulating the assembly, stability, and motor activity of the dynein/dynactin complex at the cell cortex, as well as the dynamics of mitotic microtubules. PMID: 28803871
    2. replication confirmed at genome-wide significance the association of loci at FOXE1 with hypothyroidism, and PDE8B, CAPZB and PDE10A with serum TSH. A total of 12 SNPs seemed to explain nearly 7% of the serum TSH variation PMID: 28727628
    3. At each step during spermatogenesis, the cellular localization of hCPbeta3 changed dynamically. In spermatogonia, hCPbeta3 showed a slight signal in cytoplasm. hCPbeta3 expression was conspicuous mainly from spermatocytes, and hCPbeta3 localization dynamically migrated from cytoplasm to the acrosomal cap and acrosome. In mature spermatozoa, hCPbeta3 accumulated in the postacrosomal region and less so at the midpiece of... PMID: 28104696
    4. A subject with micrognathia, cleft palate and hypotonia harbored a de novo, balanced chromosomal translocation that disrupts the CAPZB gene. The function of capzb was analyzed in the zebrafish model. PMID: 26758871
    5. CAPZB is involved in tumor progression in cases of epithelioid sarcoma (EpiS), irrespective of the INI1 expression, and may be a potential therapeutic target. The paradoxical relationship between the tumor suppressor INI1 and the oncoprotein CAPZB in the pathogenesis of EpiS remains to be clarified PMID: 26965049
    6. RAGE has a role in endothelial cell membrane repair and regulates F-actin remodeling and membrane resealing PMID: 21844192

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere.
  • 蛋白家族：
    F-actin-capping protein beta subunit family
  • 数据库链接：

    HGNC: 1491

    OMIM: 601572

    KEGG: hsa:832

    STRING: 9606.ENSP00000264202

    UniGene: Hs.432760