Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. CARMIL1 Antibody

CARMIL1 Antibody

  • 货号：
    CSB-PA713356LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of HepG2 cells with CSB-PA713356LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CARMIL1 Polyclonal antibody
  • Uniprot No.：
    Q5VZK9
  • 基因名：
    CARMIL1
  • 别名：
    Acan 125 antibody; Capping protein; Arp2/3; and myosin I linker antibody; CARMIL homolog antibody; leucine rich repeat containing 16 antibody; Leucine-rich repeat-containing protein 16A antibody; LR16A_HUMAN antibody; Lrrc16 protein antibody; LRRC16A antibody; p116 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human F-actin-uncapping protein LRRC16A protein (1184-1295AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CARMIL1 Antibody (CSB-PA713356LA01HU)，的标记方式是Non-conjugated。对于CARMIL1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA713356LB01HU CARMIL1 Antibody, HRP conjugated ELISA
    FITC CSB-PA713356LC01HU CARMIL1 Antibody, FITC conjugated
    Biotin CSB-PA713356LD01HU CARMIL1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments. Plays a role in lamellipodial protrusion formations and cell migration.
  • 基因功能参考文献：
    1. A novel genetic variant in leucine-rich repeat-containing 16A (LRRC16A) has been associated with reduced ARDS risk. PMID: 27768389
    2. LRRC16A plays a role in adult respiratory distress syndrome pathophysiology by interacting with, and being mediated through, platelets. PMID: 25254322
    3. shown for the first time that CARMIL/LRRC16A was associated with gout, which could be due to urate transportsome failure PMID: 24318514
    4. The results also suggest that the ability of CARMIL1 to inhibit CP in cells may be regulated. PMID: 23904264
    5. Data suggest that CARMIL promotes uncapping by binding to a freely accessible site on Capping protein (CP) bound to a filament barbed end and inducing a change in the conformation of the actin-binding surface of CP. PMID: 22411988
    6. The two CARMIL isoforms are both important for cell migration, but they have distinct functions.[CARMIL1, CARMIL2] PMID: 19846667

    显示更多

    收起更多

  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Cell projection, lamellipodium.
  • 蛋白家族：
    CARMIL family
  • 组织特异性：
    Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney.
  • 数据库链接：

    HGNC: 21581

    OMIM: 609593

    KEGG: hsa:55604

    STRING: 9606.ENSP00000331983

    UniGene: Hs.649550