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CC2D1A Antibody

  • 货号：
    CSB-PA004608GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6P1N0
  • 基因名：
    CC2D1A
  • 别名：
    CC2D1A antibody; AKI1Coiled-coil and C2 domain-containing protein 1A antibody; Akt kinase-interacting protein 1 antibody; Five prime repressor element under dual repression-binding protein 1 antibody; FRE under dual repression-binding protein 1 antibody; Freud-1 antibody; Putative NF-kappa-B-activating protein 023N antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CC2D1A
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses. Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.
  • 基因功能参考文献：
    1. Both expressions of CC2D1A and HTR1A genes studied on autism spectrum disorder cases and controls were significantly different PMID: 26782176
    2. CC2D1A binds to CHMP4B polymers formed on endosomes to regulate the endosomal sorting pathway.CC2D1A regulates degradation and signaling of EGFR and TLR4. PMID: 27769858
    3. Aki1 was expressed in human diffuse malignant mesothelioma specimens. Expression correlated with phosphorylated CREB1. Aki1 regulates CREB by modulating protein kinase A activity. The Aki1-CREB axis plays an important role in DMM pathogenesis. PMID: 26294214
    4. Null mutations in CC2D1A consistently cause a variable spectrum of presentations including ID, ASD, and seizures. CC2D1A regulates NF-kappaB signaling. PMID: 25066123
    5. All of the pancreatic cancer cell lines expressed Aki1. Silencing of Aki1 in Panc1 cells reduced the phosphorylation of Akt and increased the phosphorylation of cleaved PARP. PMID: 25036909
    6. Non-genomic downregulation of 5-HT1A receptor by 17betaestradiol does not involve NUDR and Freud-1 proteins. PMID: 22328058
    7. TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity PMID: 22833682
    8. CHMP4B interacts directly with CC2D1A and CC2D1B with nanomolar affinity by forming a 1:1 complex. PMID: 22406677
    9. CC2D1A interaction with CHMP4B/4A blocks HIV-1 budding. PMID: 22258254
    10. Results suggest the involvement of CC2D1A and CC2D2A in mental retardation in the Han Chinese population, and some specific haplotypes may be susceptible or protective. PMID: 22023432
    11. Reductions in Freud-1 expression in prefrontal cortex may be associated with early onset of major depressive disorder. PMID: 20392296
    12. Data suggest that the anti-tumor activity of NF-kappaB inhibitors is associated with p53-mediated activation of autophagy. PMID: 21274377
    13. central role for TAPE (CC2D1A/Freud-1/Aki-1)in linking TLR3 and TLR4 to innate immune defenses at an early step PMID: 21189260
    14. CC2D1A activates NF-kappaB through the canonical IKK pathway PMID: 20529849
    15. these results indicate that cyclin B1-Cdk1 is a kinase of Aki1 during mitosis and that its phosphorylation of Aki1 may regulate mitotic function. PMID: 20171170
    16. Centrosome-associated Aki1 and cohesin play pivotal roles in preventing premature cleavage in centriole cohesion. PMID: 19948489
    17. A protein truncating mutation was identified in the gene CC2D1A in nine consanguineous families with severe autosomal recessive mental retardation. PMID: 16033914
    18. a deletion in the CC2D1A gene has been linked to nonsyndromic mental retardation. This deletion results in the truncation of the helix-loop-helix DNA binding and the C2 domains. PMID: 17394259
    19. Freud-1 has a key role in regulating DRD2 expression PMID: 17535813
    20. disruption of transcriptional regulation by mutation of Freud-1 may play a role in abnormal brain function leading to mental retardation PMID: 17714190
    21. Results suggest that Freud-1/Aki1 is a novel receptor-selective scaffold protein for the PDK1/Akt pathway and present a new activation mechanism of Akt. PMID: 18662999
    22. Aki1 (Akt kinase-interacting protein 1)/CC2D1A/Freud-1 localized in centrosomes in addition to cytosol and in nucleus. Aki1 interacts with cohesin to prevent premature separase-mediated centriole disengagement. PMID: 19948489
    23. CC2D1A associated with epidermal growth factor receptor (EGFR) in response to EGF stimulation, and was required for Akt activation induced by EGF, but not by insulin-like growth factor 1 (IGF-1). PMID: 18662999
    24. Paper describes a function of Cc2d1a/Cc2d1b and their Drosophila homologue l(2)gd in D.melanogaster in Notch trafficking. PMID: 17084358
    25. Review of Freud-1 as a repressor of serotonin 1A receptor gene. PMID: 15534042
    26. Freud-1 mediates HDAC-independent repression of the 5-HT1A receptor promoter in neuronal 5-HT1A-positive cells. PMID: 14756806

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  • 相关疾病：
    Mental retardation, autosomal recessive 3 (MRT3)
  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    CC2D1 family
  • 数据库链接：

    HGNC: 30237

    OMIM: 608443

    KEGG: hsa:54862

    STRING: 9606.ENSP00000313601

    UniGene: Hs.269592