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CCAR1 Antibody

  • 货号：
    CSB-PA138742
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA138742(CCAR1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA138742(CCAR1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q8IX12
  • 基因名：
    CCAR1
  • 别名：
    CARP-1 antibody; Carp1 antibody; Ccar1 antibody; CCAR1_HUMAN antibody; Cell cycle and apoptosis regulatory protein 1 antibody; cell division cycle and apoptosis regulator 1 antibody; Cell division cycle and apoptosis regulator protein 1 antibody; Death inducer with SAP domain antibody; FLJ10590 antibody; FLJ10839 antibody; FLJ13376 antibody; FLJ20734 antibody; MGC7730 antibody; RP11-437A18.1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human CCAR1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells. Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells.
  • 基因功能参考文献：
    1. High CCAR1 expression tended to be an independent predictor of shorter recurrence-free survival in hepatocellular carcinoma patients after curative hepatectomy. PMID: 26511806
    2. Our data demonstrates that CCAR1 contributes to carcinogenesis in gastric cancer and is required for the survival of gastric cancer cells. Moreover, CCAR1 may serve as a diagnostic marker and a potential therapeutic target. PMID: 28230774
    3. this study provides insight into the structure and evolution of DBC1 and CCAR1, which may impact future studies on the biological functions of these proteins. PMID: 25610865
    4. necdin exerts its pro-survival activity by counteracting the action of the pro-apoptotic protein Cell Cycle Apoptosis Regulatory Protein (CCAR1/CARP1) PMID: 22905258
    5. CCAR1 is a novel partner of Ngn3 in mediating endocrine differentiation. PMID: 22266316
    6. anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction antagonists are novel regulators of cell growth and apoptosis PMID: 21903591
    7. cell cycle and apoptosis regulatory protein-1 is a novel mediator of apoptosis signaling by retinoid CD437 PMID: 12816952
    8. The study shows that tyrosine 192 of CARP-1 is a target of apoptosis signaling, and CARP-1, in turn, promotes apoptosis by activating p38 MAPK and caspase-9. PMID: 16543231
    9. CARP-1 is a suppressor of breast cancer growth, and its expression is diminished in tumors, in part, by methylation-dependent silencing PMID: 17513614
    10. Damaging exercise induced the expression of capZalpha, MCIP1, CARP1, DNAJB2, c-myc, and junD, each of which are likely involved in skeletal muscle growth, remodeling, and stress management. PMID: 18321953
    11. CCAR1 regulates expression of key proliferation-inducing genes. PMID: 18722177
    12. These results provide the first evidence for the microtubule dependent association of AKAP350A and CCAR1 with RNA stress granules. PMID: 19073175
    13. CCAR1 is a novel component of Wnt/beta-catenin signaling that plays an important role in transcriptional regulation by beta-catenin. PMID: 19520846

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  • 亚细胞定位：
    Cytoplasm, perinuclear region.
  • 组织特异性：
    Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.
  • 数据库链接：

    HGNC: 24236

    OMIM: 612569

    KEGG: hsa:55749

    STRING: 9606.ENSP00000265872

    UniGene: Hs.49853