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CCDC8 Antibody

  • 货号：
    CSB-PA880938LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of Hela cells using CSB-PA880938LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: Mouse liver tissue
      All lanes: CCDC8 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 60 kDa
      Observed band size: 60 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CCDC8 Polyclonal antibody
  • Uniprot No.：
    Q9H0W5
  • 基因名：
    CCDC8
  • 别名：
    CCDC8 antibody; CCDC8_HUMAN antibody; Coiled coil domain containing 8 antibody; Coiled-coil domain-containing protein 8 antibody; DKFZp564K0322 antibody; ENSMUSG00000041117 antibody; MGC72567 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Coiled-coil domain-containing protein 8 protein (214-513AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CCDC8 Antibody (CSB-PA880938LA01HU)，的标记方式是Non-conjugated。对于CCDC8 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA880938LB01HU CCDC8 Antibody, HRP conjugated ELISA
    FITC CSB-PA880938LC01HU CCDC8 Antibody, FITC conjugated
    Biotin CSB-PA880938LD01HU CCDC8 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:2000-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome.
  • 基因功能参考文献：
    1. Variants near TTN and CCDC8 were associated with KI67 expression, and rs2288563 and rs2562832 in TTN are potential biomarkers for the prediction of clinical outcomes in hepatitis B-related hepatocellular carcinoma patients. PMID: 28700999
    2. CCDC8 may suppress the invasion and metastasis of non-small cell lung cancer cells. PMID: 27342910
    3. CUL7, OBSL1 and CCDC8 modulate the alternative splicing of the INSR PMID: 24711643
    4. The CUL7, OBSL1, and CCDC8 proteins form a 3M complex that functions in maintaining microtubule and genome integrity and normal development. PMID: 24793695
    5. Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling. PMID: 23018678
    6. discussion of roles of CCDC8, CUL7 (cullin 7), and OBSL1 (obscurin-like 1) in growth and development using findings from patients with Miller-McKusick-Malvaux syndrome and Silver-Russell syndrome [REVIEW] PMID: 22156540
    7. p90 is a critical cofactor for p53-mediated apoptosis through promoting Tip60-mediated p53 acetylation. PMID: 22084066
    8. We propose that CUL7, OBSL1, and CCDC8 are members of a pathway controlling mammalian growth. PMID: 21737058

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  • 相关疾病：
    3M syndrome 3 (3M3)
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 组织特异性：
    Widely expressed with low levels in spleen, skeletal muscle, small intestine, kidney and liver.
  • 数据库链接：

    HGNC: 25367

    OMIM: 614145

    KEGG: hsa:83987

    STRING: 9606.ENSP00000303158

    UniGene: Hs.744359