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CCHCR1 Antibody

  • 货号：
    CSB-PA004769LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: 293T whole cell lysate, 293 whole cell lysate, HepG2 whole cell lysate, THP-1 whole cell lysate, U251 whole cell lysate
      All lanes: CCHCR1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 89, 100, 96 kDa
      Observed band size: 89 kDa
    • IHC image of CSB-PA004769LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • Immunofluorescence staining of U251 cells with CSB-PA004769LA01HU-IF at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CCHCR1 Polyclonal antibody
  • Uniprot No.：
    Q8TD31
  • 基因名：
    CCHCR1
  • 别名：
    Coiled-coil alpha-helical rod protein 1 (Alpha-helical coiled-coil rod protein) (Putative gene 8 protein) (Pg8), CCHCR1, C6orf18 HCR
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Coiled-coil alpha-helical rod protein 1 protein (281-500aa)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CCHCR1 Antibody (CSB-PA004769LA01HU)，的标记方式是Non-conjugated。对于CCHCR1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA004769LB01HU CCHCR1 Antibody, HRP conjugated ELISA
    FITC CSB-PA004769LC01HU CCHCR1 Antibody, FITC conjugated
    Biotin CSB-PA004769LD01HU CCHCR1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:100-1:500
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be a regulator of keratinocyte proliferation or differentiation.
  • 基因功能参考文献：
    1. psoriasis candidate gene CCHCR1 expressed at P-bodies and centrosomes PMID: 29866042
    2. CCHCR1 interacts specifically with the E2 protein of human papillomavirus type 16 on a surface overlapping BRD4 binding PMID: 24664238
    3. Confocal imaging confirmed the localization of CCHCR1 in P-bodies. PMID: 24858563
    4. The centrosomal localization of CCHCR1 provides a connection to the abnormal cell proliferation and offers a link to possible cellular pathways altered in psoriasis. PMID: 23189171
    5. Psoriasis is associated with genetic polymorphism in the CCHCR1 gene and in a genomic segment flanking the HLA-C region in the North Indian population. PMID: 22182809
    6. Isolated by a two hybrid assay, StAR binding protein binds StAR protein in cells and enhances the ability of StAR protein to promote syntheses of steroid hormones.(sTAR binding protein) PMID: 12909641
    7. These studies show that miR-122, a 22-nucleotide microRNA, is derived from a liver-specific noncoding polyadenylated RNA transcribed from the gene hcr. PMID: 17179747
    8. These results suggest a role for CCHCR1 in the pathogenesis of psoriasis via the regulation of skin steroid metabolism. PMID: 17221218
    9. Results show that HLA-Cw6 and CCHCR1 risk allele associations with clinical features of psoriasis are predictably highly similar in a Finnish nationwide cohort of 379 psoriasis patients. PMID: 17340018
    10. the aberrant function of CCHCR1 may lead to abnormal keratinocyte proliferation which is a key feature of psoriatic epidermis. PMID: 18174193
    11. CCHCR1 is up-regulated in skin cancer and associated with EGFR expression PMID: 19551138

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 组织特异性：
    Found in all tissues tested, abundantly expressed in heart, liver, skeletal muscle, kidney and pancreas, and to a lesser extent in lung and placenta. Overexpressed in keratinocytes of psoriatic lesions.
  • 数据库链接：

    HGNC: 13930

    OMIM: 605310

    KEGG: hsa:54535

    STRING: 9606.ENSP00000379566

    UniGene: Hs.485075