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  4. CCNA2 Antibody

CCNA2 Antibody

  • 货号：
    CSB-PA004805GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P20248
  • 基因名：
  • 别名：
    CCN1 antibody; CCNA antibody; Ccna2 antibody; CCNA2_HUMAN antibody; Cyclin A2 antibody; Cyclin-A antibody; Cyclin-A2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CCNA2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
  • 基因功能参考文献：
    1. High CCNA2 expression is associated with hepatocellular carcinoma progression. PMID: 30106440
    2. Study demonstrates that cyclin A2 interacts with actin and RhoA during mitosis, and that cyclin A2 depletion induces a dramatic decrease in active RhoA in mitosis suggesting that cyclin A2 participation in RhoA activation in late mitosis. PMID: 27279564
    3. Bisphosphonate inhibits the expression of cyclin A2 at the transcriptional level in normal human oral keratinocytes. PMID: 28713904
    4. the presented evidence suggested that WA can inhibit HCC cell proliferationand tumorigenesis through miR-22-repressed CCNA2, which was at least partially through FXR regulation PMID: 27738335
    5. Findings suggest that ERK1/2-mediated Cdk2/cyclin A signaling pathway is involved in 7-hydroxy-5,4'-dimethoxy-2-arylbenzofuran (Ary) - induced G1/S-phase arrest. PMID: 27259234
    6. some cancer cells are defective for efficient interaction between p27 and CycA-CDK complex due to qualitative alteration(s) PMID: 29098944
    7. This study shows that cocaine induces significant increases in both the astrocytic expression of cyclin A2 and the proliferation of primary human astrocytes. PMID: 27834787
    8. Low CCNA expression is associated with lung cancer progression. PMID: 27694898
    9. inhibition of PDK4 activity in Hepatocellular carcinoma cells increased cyclin E1, cyclin A2, and E2F1 proteins. PMID: 28003426
    10. An increase of cyclin A2 expression was identified for the first time in a case of splenic diffuse red pulp small B-cell lymphoma. PMID: 27761608
    11. Consistent with these findings, a genome-scale pooled RNA interference screen revealed that toxic doses of MK-1775 are suppressed by CDK2 or Cyclin A2 knockdown. These findings support G2 exit as the more significant effect of Wee1 inhibition in pancreatic cancers. PMID: 26890070
    12. Clioquinol suppressed cell cycle progression in the S-phase in SMMC-7721 hepatoma cells via the p21, p27-cyclin E,A/Cdk2 pathway. PMID: 26677902
    13. On analyzing cyclin A and B1 (CCNA and CCNB1) expression, positive staining in 90% cases of PTC were observed. The study revealed a significant difference in expression of cyclins A and B1 between classic and non-classic variants of PTC. PMID: 26706989
    14. Study describes a positive feedback loop centred on cyclin A2-Cdk2 inhibition of interphase APC/C-Cdc20 to allow further cyclin A2 accumulation and mitotic entry. PMID: 26960431
    15. PIWIL2 has a role in promoting progression of non-small cell lung cancer by inducing CDK2 and Cyclin A expression PMID: 26373553
    16. Cyclin A2-binding function of pUL21a contributes to the maintenance of a cell cycle state conducive for the completion of the human cytomegalovirus (HCMV) replication cycle. PMID: 25393019
    17. HDAC10 regulates cyclin A2 expression by deacetylating histones near the let-7 promoter. PMID: 26240284
    18. Results suggest that cyclin A2 overexpression may drive cancer by promoting AKT-dependent proliferation and survival. PMID: 24795023
    19. for the first time, we demonstrated that CTD induced G2/M phase arrest via the inhibition of Cdc25c and cyclin A and induced apoptosis was through death receptor (extrinsic), intrinsic (mitochondria) and ER stress pathways in A375. S2 cells. PMID: 25340978
    20. CCN2 is a regulator of the transition through cytokinesis during terminal erythropoiesis. PMID: 25615569
    21. CCNA2 is a biomarker for the prognosis of ER+ breast cancer and monitoring of tamoxifen efficacy PMID: 24622579
    22. our data showed that bile acid-activated FXR stimulates miR-22-silenced CCNA2, a novel pathway for FXR to exert its protective effect in the gastrointestinal tract. PMID: 25596928
    23. Expression of cycle marker cyclin A1 differs between benign and malignant papillary breast lesions. PMID: 25501285
    24. Cyclin A2 and its associated kinase (cdk2) activity are required for optimal induction of progesterone receptor target genes in breast cancer cells. PMID: 25220500
    25. It is concluded that non-response to everolimus is characterized by increased cdk2/cyclin A, driving RCC cells into the G2/M-phase. VPA hinders everolimus non-response by diminishing cdk2/cyclin A PMID: 24935000
    26. cyclin A expression predicted 100% of the patients at risk for metastasis of rectal neuroendocrine tumors. PMID: 24824027
    27. The aim of the present study was to evaluate the prognostic value of the proliferation factors mitotic activity index (MAI), phosphohistone H3 (PPH3), cyclin B1, cyclin A and Ki67, alone and in combinations. PMID: 24324728
    28. show that cyclin A is an independent prognostic factor in endometrioid adenocarcinoma PMID: 24519066
    29. level unchanged in endometrial cancer PMID: 23815208
    30. APPOLON to be a novel regulator of mitotic CYCLIN A degradation independent of SAC. PMID: 24302728
    31. Data indicate that the major tegument 150-kDa phosphoprotein (pp150) of human cytomegalovirus (HCMV) binds to cyclin A2 via a functional RXL/Cy motif resulting in its cyclin A2-dependent phosphorylation. PMID: 24101496
    32. HDAC3 regulates cyclin A stability. PMID: 23760262
    33. Cyclin A creates a cellular environment that promotes microtubule detachment from kinetochores in prometaphase to ensure efficient error correction and faithful chromosome segregation PMID: 24013174
    34. We further detected that reduced level of GRK2 induced a small cell cycle arrest at G2/M phase by enhancing the expression of cyclin A PMID: 23460259
    35. Overexpression of cyclin A2 is associated with stage I non-small cell lung cancer. PMID: 23115005
    36. human papillomavirus E4 proteins can interact with cyclin A and cdk2, which may contribute to viral manipulation of the host cell cycle. PMID: 23065011
    37. The expression of cell proliferation markers cyclin A and p27 are independent prognostic factors in patients with esophageal squamous cell carcinoma. PMID: 21762277
    38. The study has revealed that some highly differentiated human tissues express an intron-retaining cyclin A2 mRNA that induced a G1/S block in vitro. PMID: 22745723
    39. Human cytomegalovirus IE1/2 expression was downregulated by cyclin A2, CDK1 and CDK2. PMID: 22718829
    40. cyclin A and cyclin B1 are useful markers in the distinction of benign and malignant thyroid tumors PMID: 21264543
    41. GC box was responsible for the cyclic activity of human CKAP2 promoter through the phosphorylation of Sp1, possibly by Cyclin A/Cdk complex. PMID: 22465120
    42. Data demonstrated that in addition to galectin-3, HK III and cyclin A profiles could be important biomarkers in predicting malignancy in follicular thyroid nodules. PMID: 17868400
    43. Cyclin A2 negatively controls cell motility by promoting RhoA activation, thus demonstrating a novel Cyclin A2 function in cytoskeletal rearrangements and cell migration. PMID: 22232705
    44. NF-Y binds to CCAAT sequences in the Cyclin A promoter, as well as to those in the promoters of cell cycle G2 regulators such as CDC2, Cyclin B and CDC25C. PMID: 21871181
    45. These data demonstrate that B55alpha acts to antagonize Cyclin A/Cdk-dependent activation of FoxM1, to ensure that FoxM1 activity is restricted to the G(2) phase of the cell cycle. PMID: 21813648
    46. The current results suggested that an SNP (rs769236) at the promoter of CCNA2 may be associated significantly with increased risk of colon, liver, and lung cancers. PMID: 21858804
    47. The expression of mRNA and protein of Cyclin A in hypertrophic scar changes from high level to low level as the hypertrophic scar develops, while the expression of P21cip1 changes from low level to high level. PMID: 21046779
    48. Low p16(Ink4a) expression, overexpression of p53, cytoplasmic p27(Kip1), and Cyclin A are predictive markers for shorter overall survival in ovarian carcinomas. PMID: 21464733
    49. cyclin A was strongly associated with the expression of cyclin E in invasive ductal breast carcinoma PMID: 21472690
    50. Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A PMID: 21336306

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Cyclin family, Cyclin AB subfamily
  • 数据库链接：

    HGNC: 1578

    OMIM: 123835

    KEGG: hsa:890

    STRING: 9606.ENSP00000274026

    UniGene: Hs.58974